Bilateral periorbital leukemia cutis presenting as suspected cellulitis.

Autor: Gupta L; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, USA., Levoska MA; Department of Dermatology, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Sharma T; Department of Dermatology, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Honda K; Department of Dermatology, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA., Prendes MA; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Jazyk: angličtina
Zdroj: Orbit (Amsterdam, Netherlands) [Orbit] 2022 Aug; Vol. 41 (4), pp. 506-508. Date of Electronic Publication: 2021 Mar 07.
DOI: 10.1080/01676830.2021.1893343
Abstrakt: Many conditions present with periorbital edema and erythema, mimicking preseptal cellulitis. We report the unique case of a patient with relapsed monoblastic mutant isocitrate dehydrogenase-2 (IDH2) acute myeloid leukemia (AML) who presented with periorbital edema and erythema, unresponsive to antibiotics. Histopathology from punch biopsy was consistent with leukemia cutis. The patient responded rapidly to the initiation of enasidenib, a novel targeted inhibitor of mutant IDH2 enzymes. Our case highlights the importance of considering leukemia cutis in patients with a history of leukemia presenting with periorbital edema and erythema.
Databáze: MEDLINE
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