The association between maternal cadmium exposure and small for gestational age: a systematic review and meta-analysis.

Autor: Habibian Sezavar A; Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran., Abyareh M; Department of Environment, Faculty of Natural Resources, Yazd University, Yazd, Iran., Fahimi R; Medical Research Center, Kateb University, Kabul, Afghanistan., Nyasulu PS; Division of Epidemiology & Biostatistics, Faculty of Medicine & Health Sciences, Stellenbosch University, Cape Town, South Africa., Abyadeh M; Department of Molecular Systems Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Jazyk: angličtina
Zdroj: International journal of environmental health research [Int J Environ Health Res] 2022 Jul; Vol. 32 (7), pp. 1469-1477. Date of Electronic Publication: 2021 Mar 03.
DOI: 10.1080/09603123.2021.1892035
Abstrakt: Several observational studies have found an association between maternal Cadmium (Cd) exposure and Small for Gestational Age (SGA). However, these findings are inconsistent. We conducted this meta-analysis to evaluate the relationship between maternal cadmium exposure and SGA risk. A comprehensive search was performed through PubMed, Scopus, Embase, Web of Science, Cochrane Library and OpenGrey to retrieve all pertinent studies published before October 2020. A combined odds ratio (OR) and corresponding 95% confidence interval (CI) were employed to examine this correlation. As a result, nine eligible studies met the inclusion criteria and were included in a systematic review, of those six studies containing sample type of blood were included in meta-analysis, and present meta-analysis showed that maternal cadmium exposure increased the risk of SGA 1.31 times (OR = 1.31; 95% CI = 1.16-1.47 for highest versus lowest category of cadmium). This meta-analysis suggests that maternal Cd exposure may be a risk factor for SGA. However, large prospective studies from different ethnic populations with consideration of other influencing parameters are needed to confirm this finding.
Databáze: MEDLINE
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