A Roadmap to Heart Regeneration Through Conserved Mechanisms in Zebrafish and Mammals.

Autor: Brezitski KD; Division of Cardiology, Department of Medicine, Duke University Medical Center, Box 102152, Durham, NC, 27710, USA., Goff AW; Division of Cardiology, Department of Medicine, Duke University Medical Center, Box 102152, Durham, NC, 27710, USA., DeBenedittis P; Division of Cardiology, Department of Medicine, Duke University Medical Center, Box 102152, Durham, NC, 27710, USA.; Regeneration Next, Durham, NC, USA., Karra R; Division of Cardiology, Department of Medicine, Duke University Medical Center, Box 102152, Durham, NC, 27710, USA. ravi.karra@duke.edu.; Regeneration Next, Durham, NC, USA. ravi.karra@duke.edu.; Department of Pathology, Durham, NC, USA. ravi.karra@duke.edu.; Center for Aging, Durham, NC, USA. ravi.karra@duke.edu.
Jazyk: angličtina
Zdroj: Current cardiology reports [Curr Cardiol Rep] 2021 Mar 02; Vol. 23 (4), pp. 29. Date of Electronic Publication: 2021 Mar 02.
DOI: 10.1007/s11886-021-01459-6
Abstrakt: Purpose of Review: The replenishment of lost or damaged myocardium has the potential to reverse heart failure, making heart regeneration a goal for cardiovascular medicine. Unlike adult mammals, injury to the zebrafish or neonatal mouse heart induces a robust regenerative program with minimal scarring. Recent insights into the cellular and molecular mechanisms of heart regeneration suggest that the machinery for regeneration is conserved from zebrafish to mammals. Here, we will review conserved mechanisms of heart regeneration and their translational implications.
Recent Findings: Based on studies in zebrafish and neonatal mice, cardiomyocyte proliferation has emerged as a primary strategy for effecting regeneration in the adult mammalian heart. Recent work has revealed pathways for stimulating cardiomyocyte cell cycle reentry; potential developmental barriers for cardiomyocyte proliferation; and the critical role of additional cell types to support heart regeneration. Studies in zebrafish and neonatal mice have established a template for heart regeneration. Continued comparative work has the potential to inform the translation of regenerative biology into therapeutics.
Databáze: MEDLINE
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