Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus.
| Autor: | Jog NR; Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States., James JA; Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.; Departments of Medicine, Pathology, Microbiology & Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in immunology [Front Immunol] 2021 Feb 03; Vol. 11, pp. 623944. Date of Electronic Publication: 2021 Feb 03 (Print Publication: 2020). |
| DOI: | 10.3389/fimmu.2020.623944 |
| Abstrakt: | Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease. Infections or infectious reactivation are potential triggers for initiation of autoimmunity and for SLE flares. Epstein-Barr virus (EBV) is gamma herpes virus that has been associated with several autoimmune diseases such as SLE, multiple sclerosis, Sjogren's syndrome, and systemic sclerosis. In this review, we will discuss the recent advances regarding how EBV may contribute to immune dysregulation, and how these mechanisms may relate to SLE disease progression. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Jog and James.) |
| Databáze: | MEDLINE |
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