Surveillance of post-cataract endophthalmitis at a tertiary referral center: a 10-year critical evaluation.

Autor: Kato JM; Department of Ophthalmology-LIM33, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, 255 Av. Dr. Enéas Carvalho de Aguiar, São Paulo, Brazil. juliana.kato@hc.fm.usp.br., Tanaka T; Department of Ophthalmology-LIM33, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, 255 Av. Dr. Enéas Carvalho de Aguiar, São Paulo, Brazil., de Oliveira LMS; Department of Ophthalmology-LIM33, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, 255 Av. Dr. Enéas Carvalho de Aguiar, São Paulo, Brazil., de Oliveira MS; Division of Infectious and Parasitic Diseases, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Rossi F; Central Laboratory Division-LIM03, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Goldbaum M; Department of Ophthalmology-LIM33, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, 255 Av. Dr. Enéas Carvalho de Aguiar, São Paulo, Brazil., Pimentel SLG; Department of Ophthalmology-LIM33, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, 255 Av. Dr. Enéas Carvalho de Aguiar, São Paulo, Brazil., de Almeida Junior JN; Central Laboratory Division-LIM03, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.; Institute of Tropical Medicine-LIM53, University of São Paulo (USP), São Paulo, Brazil., Yamamoto JH; Department of Ophthalmology-LIM33, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, 255 Av. Dr. Enéas Carvalho de Aguiar, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: International journal of retina and vitreous [Int J Retina Vitreous] 2021 Feb 16; Vol. 7 (1), pp. 14. Date of Electronic Publication: 2021 Feb 16.
DOI: 10.1186/s40942-021-00280-1
Abstrakt: Background: Acute post-cataract endophthalmitis (APE) is a rare complication potentially causing irreversible visual loss. A 10-year study of APE was conducted to determine its incidence, microbiological spectra and antibiotic resistance profile of APE-related pathogens at a major tertiary referral center in Brazil.
Methods: APE cases reported between January 2010 and December 2019 were included. Phacoemulsification and extracapsular cataract techniques were eligible; combined procedures, traumatic and congenital cataract were excluded. Vitreous samples were cultured and antimicrobial resistance was compared for the periods of 2010-2014 and 2015-2019. The results were analyzed with Fisher's exact test.
Results: Our sample consisted of 40,491 cataract surgeries and 51 (0.126%) APE cases. Culture was positive in 35 cases (71.4%), of which 31 (88.6%) Gram-positive, 3 (8.6%) Gram-negative, and 1 (2.9%) fungal. The most frequently isolated organism was Staphylococcus epidermidis (n = 17/35, 48.6%), followed by Staphylococcus aureus (n = 4/35, 11.4%). From 2010-2014 to 2015-2019, antimicrobial resistance increased against moxifloxacin (11.1-54.5%, p = 0.07), ciprofloxacin (54.5-72.7%, p = 0.659) and oxacillin (66.7-93.3%, p = 0.13).
Conclusions: The observed incidence and microbial spectra were compatible with previous studies. A trend towards growing moxifloxacin and ciprofloxacin resistance was observed. Surveillance remains crucial to prevent treatment failure from antimicrobial resistance.
Databáze: MEDLINE
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