Role of microsomal ethanol-oxidizing system in regulation of linoleoyl-CoA desaturase activity after long-term ethanol administration.

Autor: Buko VU; Institute of Biochemistry, Byelorussian SSR Academy of Sciences, Grodno., Sushko LI
Jazyk: angličtina
Zdroj: Alcohol and alcoholism (Oxford, Oxfordshire) [Alcohol Alcohol] 1988; Vol. 23 (1), pp. 69-71.
Abstrakt: Chronic ethanol administration resulted in a decrease of rat liver linoleoyl-CoA desaturase activity and an activation of MEOS. This was accompanied by an increase in the activity of the NADPH-dependent system and the oxidation rate of NADH-oxidase, which suggests transfer of electrons from NADH to cytochrome P-450. The decreased linoleoyl-CoA desaturase activity may be due to insufficient supply of electrons, because of possible diversion to MEOS.
Databáze: MEDLINE