High-resolution mapping identifies HLA class II associations with multifocal motor neuropathy.

Autor: Bos JW; UMC Utrecht Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, Utrecht, the Netherlands., Otten HG; Department of Immunology, University Medical Center Utrecht, Utrecht, the Netherlands., Herraets IJT; UMC Utrecht Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, Utrecht, the Netherlands., Goedee HS; UMC Utrecht Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, Utrecht, the Netherlands., Cats EA; UMC Utrecht Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, Utrecht, the Netherlands., de Hoop T; Department of Immunology, University Medical Center Utrecht, Utrecht, the Netherlands., Verduijn W; Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, the Netherlands., van der Pol WL; UMC Utrecht Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, Utrecht, the Netherlands., van den Berg LH; UMC Utrecht Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, Utrecht, the Netherlands. Electronic address: l.h.vandenberg@umcutrecht.nl.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2021 May; Vol. 101, pp. 79-84. Date of Electronic Publication: 2021 Jan 20.
DOI: 10.1016/j.neurobiolaging.2021.01.014
Abstrakt: Objective: To gain further insight in the immunopathology underlying multifocal motor neuropathy (MMN) by exploring the association between MMN and the human leukocyte antigen (HLA) class II DRB1, DQB1, and DQA loci in depth and by correlating associated haplotypes to detailed clinical and anti-ganglioside antibody data.
Methods: We performed high-resolution HLA-class II typing for the DRB1, DQB1, and DQA1 loci in 126 well-characterized MMN patients and assessed disease associations with haplotypes. We used a cohort of 1305 random individuals as a reference for haplotype distribution in the Dutch population.
Results: The DRB1*15:01-DQB1*06:02 haplotype (OR 1.6 [95% CI 1.1-2.2], p < 0.05) and the DRB1*12:01-DQB1*03:01 haplotype (OR 2.7 [95% CI 1.2-5.5], p < 0.05) were more frequent in patients with MMN than in controls. These haplotypes were not associated with disease course, response to treatment or anti-ganglioside antibodies.
Conclusions: MMN is associated with the DRB1*15:01-DQB1*06:02 and DRB1*12:01-DQB1*03:01 haplotypes. These HLA molecules or gene variants in their immediate vicinity may promote the specific inflammatory processes underlying MMN.
(Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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