Bioactive 1,2,3-Triazoles: An Account on their Synthesis, Structural Diversity and Biological Applications.

Autor: da S M Forezi L; Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Campus do Valonguinho, 24020-150, Niterói, RJ, Brazil., Lima CGS; Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Campus do Valonguinho, 24020-150, Niterói, RJ, Brazil., Amaral AAP; Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Campus do Valonguinho, 24020-150, Niterói, RJ, Brazil., Ferreira PG; Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, R. Dr. Mario Vianna, 523 - Santa Rosa, 24241-000, Niterói, RJ, Brazil., de Souza MCBV; Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Campus do Valonguinho, 24020-150, Niterói, RJ, Brazil., Cunha AC; Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Campus do Valonguinho, 24020-150, Niterói, RJ, Brazil., de C da Silva F; Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Campus do Valonguinho, 24020-150, Niterói, RJ, Brazil., Ferreira VF; Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, R. Dr. Mario Vianna, 523 - Santa Rosa, 24241-000, Niterói, RJ, Brazil.
Jazyk: angličtina
Zdroj: Chemical record (New York, N.Y.) [Chem Rec] 2021 Oct; Vol. 21 (10), pp. 2782-2807. Date of Electronic Publication: 2021 Feb 11.
DOI: 10.1002/tcr.202000185
Abstrakt: The triazole heterocycle is a privileged scaffold in medicinal chemistry, since its structure is present in a large number of biologically active molecules, including several drugs currently in the market. Due to their vast applications, a wide variety of methods are described for their preparation, such as the 1,3-dipolar cycloaddition and processes involving diazo compounds and diazo transfer reactions. Considering the significant number of contributions from our research group to this chemistry in recent decades, in this account we discuss both the development of new methods for the synthesis of 1,2,3-triazoles and the preparation of new triazole-functionalized biologically active molecules using classical approaches.
(© 2021 The Chemical Society of Japan & Wiley-VCH GmbH.)
Databáze: MEDLINE
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