An Optimized Extract, Named Self-Growth Colony, from Platelet-Rich Plasma Shows Robust Skin Rejuvenation and Anti-Ageing Properties: A Novel Technology in Development of Cosmetics.

Autor:	Chan GKL; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, Shenzhen Research Institute, Shenzhen, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China., Guo MS; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, Shenzhen Research Institute, Shenzhen, China., Dai DK; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, Shenzhen Research Institute, Shenzhen, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China., Lai QWS; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, Shenzhen Research Institute, Shenzhen, China., Fung KWC; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, Shenzhen Research Institute, Shenzhen, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China., Zheng BZ; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, Shenzhen Research Institute, Shenzhen, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China., Wu KQ; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, Shenzhen Research Institute, Shenzhen, China., Man BKK; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China., Dong TT; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, Shenzhen Research Institute, Shenzhen, China.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China., Tsim KWK; Shenzhen Key Laboratory of Edible and Medicinal Bioresources, Shenzhen Research Institute, Shenzhen, China, botsim@ust.hk.; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China, botsim@ust.hk.
Jazyk:	angličtina
Zdroj:	Skin pharmacology and physiology [Skin Pharmacol Physiol] 2021; Vol. 34 (2), pp. 74-85. Date of Electronic Publication: 2021 Feb 08.
DOI:	10.1159/000513052
Abstrakt:	Introduction: Inspired by application of platelet-rich plasma (PRP) in skin treatment during injuries, an extracting method was developed here to recover high amounts of cytokines and growth factors from PRP; this prepared extract was named as self-growth colony (SGC). Methods: In optimization of SGC preparation, various parameters were tested, for example, centrifugation force, freeze-thaw, sonication, and inclusion of calcium chelator. The amounts of cytokines and growth factors, including platelet factor 4, β-thromboglobulin, epidermal growth factor, vascular endothelial growth factor, platelet-derived growth factor, were measured by ELISA assay. Results: By comparing to PRP, the prepared SGC contained a significant higher amount of measured growth factors. In addition, the degradation of growth factors within SGC during the storage was calibrated, which showed better stability as compared to that of PRP preparation. Having possible application in skin care, the optimized SGC was chemically standardized by using the enrichment of growth factors. Application of SGC in cultured keratinocytes stimulated the wound healing of injured cultures. In line to this notion, SGC was applied onto human skin, and thereafter the robust improvement of skin properties was revealed. Conclusions: The potential application of SGC in treating skin rejuvenation and ageing, as well as its elaborated application for medical purpose, that is, wound healing, was illustrated. (© 2021 S. Karger AG, Basel.)
Databáze:	MEDLINE
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