Urine stem cells are equipped to provide B cell survival signals.

Autor: Zidan AA; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.; Department of Medical Histology and Cell Biology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Centre of Excellence for Research in Regenerative Medicine Applications, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Perkins GB; Department of Molecular & Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia., Al-Hawwas M; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia., Elhossiny A; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA., Yang J; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.; School of Pharmacy, Kunming Medical University, Kunming, People's Republic of China., Bobrovskaya L; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia., Mourad GM; Department of Medical Histology and Cell Biology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Centre of Excellence for Research in Regenerative Medicine Applications, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Zhou XF; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia., Hurtado PR; Department of Renal Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.; School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Jazyk: angličtina
Zdroj: Stem cells (Dayton, Ohio) [Stem Cells] 2021 Jun; Vol. 39 (6), pp. 803-818. Date of Electronic Publication: 2021 Feb 13.
DOI: 10.1002/stem.3351
Abstrakt: The interplay between mesenchymal stem cells (MSCs) and immune cells has been studied for MSCs isolated from different tissues. However, the immunomodulatory capacity of urine stem cells (USCs) has not been adequately researched. The present study reports on the effect of USCs on peripheral blood lymphocytes. USCs were isolated and characterized before coculture with resting and with anti-CD3/CD28 bead stimulated lymphocytes. Similarly to bone marrow mesenchymal stem cells (BM-MSCs), USCs inhibited the proliferation of activated T lymphocytes and induced their apoptosis. However, they also induced strong activation, proliferation, and cytokine and antibody production by B lymphocytes. Molecular phenotype and supernatant analysis revealed that USCs secrete a range of cytokines and effector molecules, known to play a central role in B cell biology. These included B cell-activating factor (BAFF), interleukin 6 (IL-6) and CD40L. These findings raise the possibility of an unrecognized active role for kidney stem cells in modulating local immune cells.
(© 2021 The Authors. Stem Cells published by Wiley Periodicals LLC on behalf of AlphaMed Press 2021.)
Databáze: MEDLINE
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