Risk of Clinical Severity by Age and Race/Ethnicity Among Adults Hospitalized for COVID-19-United States, March-September 2020.

Autor: Pennington AF; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Kompaniyets L; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Summers AD; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Danielson ML; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Goodman AB; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Commissioned Corps, United States Public Health Service, Rockville, Maryland, USA., Chevinsky JR; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Preston LE; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Schieber LZ; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Namulanda G; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Courtney J; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Strosnider HM; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Boehmer TK; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Commissioned Corps, United States Public Health Service, Rockville, Maryland, USA., Mac Kenzie WR; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.; Commissioned Corps, United States Public Health Service, Rockville, Maryland, USA., Baggs J; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Gundlapalli AV; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2020 Dec 28; Vol. 8 (2), pp. ofaa638. Date of Electronic Publication: 2020 Dec 28 (Print Publication: 2021).
DOI: 10.1093/ofid/ofaa638
Abstrakt: Background: Older adults and people from certain racial and ethnic groups are disproportionately represented in coronavirus disease 2019 (COVID-19) hospitalizations and deaths.
Methods: Using data from the Premier Healthcare Database on 181   813 hospitalized adults diagnosed with COVID-19 during March-September 2020, we applied multivariable log-binomial regression to assess the associations between age and race/ethnicity and COVID-19 clinical severity (intensive care unit [ICU] admission, invasive mechanical ventilation [IMV], and death) and to determine whether the impact of age on clinical severity differs by race/ethnicity.
Results: Overall, 84   497 (47%) patients were admitted to the ICU, 29   078 (16%) received IMV, and 27   864 (15%) died in the hospital. Increased age was strongly associated with clinical severity when controlling for underlying medical conditions and other covariates; the strength of this association differed by race/ethnicity. Compared with non-Hispanic White patients, risk of death was lower among non-Hispanic Black patients (adjusted risk ratio, 0.96; 95% CI, 0.92-0.99) and higher among Hispanic/Latino patients (risk ratio [RR], 1.15; 95% CI, 1.09-1.20), non-Hispanic Asian patients (RR, 1.16; 95% CI, 1.09-1.23), and patients of other racial and ethnic groups (RR, 1.13; 95% CI, 1.06-1.21). Risk of ICU admission and risk of IMV were elevated among some racial and ethnic groups.
Conclusions: These results indicate that age is a driver of poor outcomes among hospitalized persons with COVID-19. Additionally, clinical severity may be elevated among patients of some racial and ethnic minority groups. Public health strategies to reduce severe acute respiratory syndrome coronavirus 2 infection rates among older adults and racial and ethnic minorities are essential to reduce poor outcomes.
(Published by Oxford University Press on behalf of Infectious Diseases Society of America 2020.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje