Kinematic Measures of Bimanual Performance are Associated With Callosum White Matter Change in People With Chronic Stroke.

Autor:	Lench DH; Departments of Psychiatry and Neurosciences, College of Medicine, Medical University of South Carolina, Charleston, SC., Hutchinson S; Department of Health Research, College of Health Professions, Medical University of South Carolina, Charleston, SC., Woodbury ML; Department of Health Research, College of Health Professions, Medical University of South Carolina, Charleston, SC., Hanlon CA; Departments of Psychiatry and Neurosciences, College of Medicine, Medical University of South Carolina, Charleston, SC.; Department of Health Research, College of Health Professions, Medical University of South Carolina, Charleston, SC.; Department of Cancer Biology, College of Medicine, Wake Forest Health Sciences, Winston-Salem, NC.
Jazyk:	angličtina
Zdroj:	Archives of rehabilitation research and clinical translation [Arch Rehabil Res Clin Transl] 2020 Jul 18; Vol. 2 (4), pp. 100075. Date of Electronic Publication: 2020 Jul 18 (Print Publication: 2020).
DOI:	10.1016/j.arrct.2020.100075
Abstrakt:	Objectives: To investigate the relationship between bimanual performance deficits measured using kinematics and callosum (CC) white matter changes that occur in people with chronic stroke. Design: Cross-sectional, observational study of participants with chronic stroke and age-matched controls. Setting: Recruitment and assessments occurred at a stroke recovery research center. Behavioral assessments were performed in a controlled laboratory setting. Magnetic resonance imaging scans were performed at the Center for Biomedical Imaging. Participants: Individuals were enrolled and completed the study (N=39; 21 participants with chronic stroke; 18 age-matched controls with at least 2 stroke risk factors). Main Outcome Measures: Diffusion imaging metrics were obtained for each individual's CC and corticospinal tract (CST), including mean kurtosis (MK) and fractional anisotropy (FA). A battery of motor assessments, including bimanual kinematics, were collected from individuals while performing bimanual reaching. Results: Participants with stroke had lower FA and MK in the CST of the lesioned hemisphere when compared with the non-lesioned hemisphere. The FA and MK values in the CST were correlated with measures of unimanual hand performance. In addition, participants with stroke had significantly lower FA and MK in the CC than matched controls. CC diffusion metrics positively correlated with hand asymmetry and trunk displacement during bimanual performance, even when correcting for age and lesion volume. Conclusions: These data confirm previous studies that linked CST integrity to unimanual performance and provide new data demonstrating a link between CC integrity and both bimanual motor deficits and compensatory movements. (© 2020 The Authors.)
Databáze:	MEDLINE
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