Creatine Metabolism in Female Reproduction, Pregnancy and Newborn Health.

Autor:	Muccini AM; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC 3800, Australia., Tran NT; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.; School of Health & Biomedical Sciences, RMIT University, Bundoora, VIC 3082, Australia., de Guingand DL; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC 3800, Australia., Philip M; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC 3220, Australia., Della Gatta PA; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC 3220, Australia., Galinsky R; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC 3800, Australia., Sherman LS; Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA.; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Kelleher MA; Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR 37009, USA., Palmer KR; Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC 3800, Australia., Berry MJ; Capital and Coast District Health Board, Department of Paediatrics, University of Otago Wellington, Wellington 6242, New Zealand., Walker DW; School of Health & Biomedical Sciences, RMIT University, Bundoora, VIC 3082, Australia., Snow RJ; Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC 3220, Australia., Ellery SJ; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC 3800, Australia.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2021 Feb 02; Vol. 13 (2). Date of Electronic Publication: 2021 Feb 02.
DOI:	10.3390/nu13020490
Abstrakt:	Creatine metabolism is an important component of cellular energy homeostasis. Via the creatine kinase circuit, creatine derived from our diet or synthesized endogenously provides spatial and temporal maintenance of intracellular adenosine triphosphate (ATP) production; this is particularly important for cells with high or fluctuating energy demands. The use of this circuit by tissues within the female reproductive system, as well as the placenta and the developing fetus during pregnancy is apparent throughout the literature, with some studies linking perturbations in creatine metabolism to reduced fertility and poor pregnancy outcomes. Maternal dietary creatine supplementation during pregnancy as a safeguard against hypoxia-induced perinatal injury, particularly that of the brain, has also been widely studied in pre-clinical in vitro and small animal models. However, there is still no consensus on whether creatine is essential for successful reproduction. This review consolidates the available literature on creatine metabolism in female reproduction, pregnancy and the early neonatal period. Creatine metabolism is discussed in relation to cellular bioenergetics and de novo synthesis, as well as the potential to use dietary creatine in a reproductive setting. We highlight the apparent knowledge gaps and the research "road forward" to understand, and then utilize, creatine to improve reproductive health and perinatal outcomes.
Databáze:	MEDLINE
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