Human marginal zone B cell development from early T2 progenitors.

Autor:	Tull TJ; School of Immunology and Microbial Sciences, King's College London, London, UK., Pitcher MJ; School of Immunology and Microbial Sciences, King's College London, London, UK., Guesdon W; School of Immunology and Microbial Sciences, King's College London, London, UK., Siu JHY; Department of Surgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK., Lebrero-Fernández C; Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Zhao Y; School of Immunology and Microbial Sciences, King's College London, London, UK., Petrov N; Biomedical Research Centre, Guy's and St. Thomas' NHS Trust, London, UK., Heck S; Biomedical Research Centre, Guy's and St. Thomas' NHS Trust, London, UK., Ellis R; Biomedical Research Centre, Guy's and St. Thomas' NHS Trust, London, UK., Dhami P; Biomedical Research Centre, Guy's and St. Thomas' NHS Trust, London, UK., Kadolsky UD; Biomedical Research Centre, Guy's and St. Thomas' NHS Trust, London, UK., Kleeman M; Biomedical Research Centre, Guy's and St. Thomas' NHS Trust, London, UK., Kamra Y; Biomedical Research Centre, Guy's and St. Thomas' NHS Trust, London, UK., Fear DJ; School of Immunology and Microbial Sciences, King's College London, London, UK., John S; School of Immunology and Microbial Sciences, King's College London, London, UK., Jassem W; Liver Transplant Unit, Institute of Liver Studies, King's College Hospital, Denmark Hill, London, UK., Groves RW; St John's Institute of Dermatology, King's College London, Guy's Campus, London, UK., Sanderson JD; Department of Gastroenterology, Guy's and St Thomas' NHS Trust, Guy's Hospital, London, UK., Robson MG; School of Immunology and Microbial Sciences, King's College London, London, UK., D'Cruz DP; School of Immunology and Microbial Sciences, King's College London, London, UK., Bemark M; Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Clinical Immunology and Transfusion Medicine, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Spencer J; School of Immunology and Microbial Sciences, King's College London, London, UK.
Jazyk:	angličtina
Zdroj:	The Journal of experimental medicine [J Exp Med] 2021 Apr 05; Vol. 218 (4).
DOI:	10.1084/jem.20202001
Abstrakt:	B cells emerge from the bone marrow as transitional (TS) B cells that differentiate through T1, T2, and T3 stages to become naive B cells. We have identified a bifurcation of human B cell maturation from the T1 stage forming IgMhi and IgMlo developmental trajectories. IgMhi T2 cells have higher expression of α4β7 integrin and lower expression of IL-4 receptor (IL4R) compared with the IgMlo branch and are selectively recruited into gut-associated lymphoid tissue. IgMhi T2 cells also share transcriptomic features with marginal zone B cells (MZBs). Lineage progression from T1 cells to MZBs via an IgMhi trajectory is identified by pseudotime analysis of scRNA-sequencing data. Reduced frequency of IgMhi gut-homing T2 cells is observed in severe SLE and is associated with reduction of MZBs and their putative IgMhi precursors. The collapse of the gut-associated MZB maturational axis in severe SLE affirms its existence in health. Competing Interests: Disclosures: The authors declare no competing interests exist. (© 2021 Tull et al.)
Databáze:	MEDLINE
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