Normal Routine Spirometry Can Mask COPD/Emphysema in Symptomatic Smokers.
Autor: | Gelb AF; Pulmonary Division, Department of Medicine, Lakewood Regional Medical Center, Lakewood, California, United States and David Geffen School of Medicine at University of California-Los Angeles Health Sciences, Los Angeles, California, United States., Yamamoto A; Department of Pathology, Lakewood Regional Medical Center, Lakewood, California, United States., Verbeken EK; Department of Pathology, Katholieke Univeritair Ziekenhuis Gasthuisberg, Leuven, Belgium., Hogg JC; University of British Columbia James Hogg Research Centre, St. Paul`s Hospital Vancouver, British Columbia, Canada., Tashkin DP; Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California-Los Angeles Health Sciences, Los Angeles, California, United States., Tran DNT; Independent pulmonary function investigator, Lakewood, California, United States., Moridzadeh RM; Independent pulmonary function investigator, Lakewood, California, United States., Fraser C; Independent pulmonary function investigator, Lakewood, California, United States., Schein MJ; Department of Radiology, Lakewood Regional Medical Center, Lakewood, California, United States., Decramer M; Department of Clinical and Experimental Medicine, Katholieke Univeritair Leuven-University of Leuven and University Hospitals Leuven, Leuven, Belgium., Glassy EF; Affiliated Pathologists Medical Group, Rancho Dominguez, California, United States., Nadel JA; Cardiovascular Research Institute and Departments of Medicine, Physiology, and Radiology, School of Medicine, University of California San Francisco, San Francisco, California, United States. |
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Jazyk: | angličtina |
Zdroj: | Chronic obstructive pulmonary diseases (Miami, Fla.) [Chronic Obstr Pulm Dis] 2021 Jan; Vol. 8 (1). |
DOI: | 10.15326/jcopdf.2020.0176 |
Abstrakt: | Background: Recent studies have emphasized the difficulty of early detection of chronic obstructive pulmonary disease (COPD) in symptomatic smokers with normal routine spirometry. This includes post-bronchodilator normal forced expiratory volume in 1 second (FEV Methods: Expiratory airflow at high and low lung volumes post-bronchodilator were measured and correlated with lung computed tomography (CT) and lung pathology (6 patients) in 16 symptomatic, treated smokers, and all with normal routine spirometry. Results: Despite normal routine spirometry, all16 patients had isolated, abnormal forced expiratory flow at 75% of FVC (FEF Conclusion: This study confirms our earlier observations that detection of small airways obstruction and/or emphysema, in symptomatic smokers with normal routine spirometry, requires analysis of expiratory airflow at low lung volumes, including FEF (JCOPDF © 2021.) |
Databáze: | MEDLINE |
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