Clinical Characteristics of Juvenile Idiopathic Inflammatory Myopathy and Comparison With Adult Patients: Analysis From a Multicentric Cohort in Spain.

Autor:	Loarce-Martos J; From the Hospital Universitario Ramón y Cajal., Larena C; From the Hospital Universitario Ramón y Cajal., Blázquez MÁ; From the Hospital Universitario Ramón y Cajal., Joven BE; Hospital Universitario 12 de Octubre., Carreira PE; Hospital Universitario 12 de Octubre., Martínez-Barrio J; Hospital Universitario Gregorio Marañón., Monteagudo I; Hospital Universitario Gregorio Marañón., López-Longo FJ; Hospital Universitario Gregorio Marañón., Ruiz L; Hospital Universitario Niño Jesús., López-Robledillo JC; Hospital Universitario Niño Jesús., Almodóvar R; Hospital Universitario Fundación Alcorcón., Llorente I; Hospital Universitario La Princesa., Tomero E; Hospital Universitario La Princesa., García-de la Peña P; Hospital Universitario HM Sanchinarro., Moruno H; Hospital Universitario Príncipe de Asturias., Pérez A; Hospital Universitario Príncipe de Asturias., Cobo-Ibáñez T; Hospital Universitario Infanta Sofía., Lojo Oliveira L; Hospital Universitario Infanta Leonor., Barbadillo MC; Hospital Universitario Puerta de Hierro., García-De Yébenes MJ; Instituto de Salud Musculoesquelética., Nuño-Nuño L; Hospital Universitario La Paz, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases [J Clin Rheumatol] 2022 Jan 01; Vol. 28 (1), pp. e195-e202.
DOI:	10.1097/RHU.0000000000001696
Abstrakt:	Methods: This study reviewed the medical records of patients from the REMICAM cohort, a multicentric longitudinal study carried out in patients with IIM, followed up between 1980 and 2014 in 12 hospitals in Madrid, Spain. Patients with definite or probable JPM, JDM, adult DM, and adult PM according to the modified Bohan and Peter criteria were selected. We compared the characteristics between JDM and JPM, and between JIIM and adult IIM. Results: Eighty-six juvenile patients (75 JDMs and 11 JPMs) and 283 adult patients (133 DMs and 150 PMs) were included. Compared with patients with JDM, patients with JPM were older at diagnosis, had more fever and arthritis, and were less frequently treated with disease-modifying antirheumatic drugs (these differences were not statistically significant). Compared with patients with adult DM, those with JDM presented more frequently with calcinosis (33.8% vs 6.9%, p < 0.0001) and had less severe infections (4.3% vs 23.4%, p < 0.0001), malignancies (1.3% vs 25.6%, p < 0.0001), and mortality (3.5% vs 33%, p < 0.0001). Patients with JDM were treated less frequently with azathioprine (10.8% vs 44.7%, p < 0.0001). Conclusions: Our findings confirm that JIIMs are a heterogeneous group of diseases with relevant differences compared with adult IIMs. Competing Interests: The authors declare no conflict of interest. (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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