Viral pathogenesis of SARS-CoV-2 infection and male reproductive health.

Autor:	Roychoudhury S; Department of Life Science and Bioinformatics, Assam University, Silchar, India., Das A; Department of Life Science and Bioinformatics, Assam University, Silchar, India., Jha NK; Department of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida, UP, India., Kesari KK; Department of Applied Physics, School of Science, Aalto University, Espoo, Finland., Roychoudhury S; Department of Microbiology, R. G. Kar Medical College and Hospital, Kolkata, India.; Health Centre, Assam University, Silchar, India., Jha SK; Department of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida, UP, India., Kosgi R; Department of Urology and Andrology, AIG Hospitals, Gachibowli, Hyderabad, India., Choudhury AP; Department of Obstetrics and Gynecology, Silchar Medical College and Hospital, Silchar, India., Lukac N; Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Nitra, Slovak Republic., Madhu NR; Department of Zoology, Acharya Prafulla Chandra College, New Barrackpore, North 24 Parganas, West Bengal, India., Kumar D; Amity Institute of Molecular Medicine and Stem Cell Research, Amity University, Noida, India., Slama P; Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, Brno, Czech Republic.
Jazyk:	angličtina
Zdroj:	Open biology [Open Biol] 2021 Jan; Vol. 11 (1), pp. 200347. Date of Electronic Publication: 2021 Jan 20.
DOI:	10.1098/rsob.200347
Abstrakt:	Coronavirus disease 2019 (COVID-19) has emerged as a new public health crisis, threatening almost all aspects of human life. Originating in bats, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted to humans through unknown intermediate hosts, where it is primarily known to cause pneumonia-like complications in the respiratory system. Organ-to-organ transmission has not been ruled out, thereby raising the possibility of the impact of SARS-CoV-2 infection on multiple organ systems. The male reproductive system has been hypothesized to be a potential target of SARS-CoV-2 infection, which is supported by some preliminary evidence. This may pose a global threat to male fertility potential, as men are more prone to SARS-CoV-2 infection than women, especially those of reproductive age. Preliminary reports have also indicated the possibility of sexual transmission of SARS-CoV-2. It may cause severe complications in infected couples. This review focuses on the pathophysiology of potential SARS-CoV-2 infection in the reproductive organs of males along with their invasion mechanisms. The risks of COVID-19 on male fertility as well as the differences in vulnerability to SARS-CoV-2 infection compared with females have also been highlighted.
Databáze:	MEDLINE
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