Harnessing Mechanobiology for Tissue Engineering.

Autor:	Kim S; Department of Biomedical Engineering and the Biological Design Center, Boston University, Boston, MA 02215, USA; The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA., Uroz M; Department of Biomedical Engineering and the Biological Design Center, Boston University, Boston, MA 02215, USA; The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA., Bays JL; Department of Biomedical Engineering and the Biological Design Center, Boston University, Boston, MA 02215, USA; The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA., Chen CS; Department of Biomedical Engineering and the Biological Design Center, Boston University, Boston, MA 02215, USA; The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA. Electronic address: chencs@bu.edu.
Jazyk:	angličtina
Zdroj:	Developmental cell [Dev Cell] 2021 Jan 25; Vol. 56 (2), pp. 180-191. Date of Electronic Publication: 2021 Jan 15.
DOI:	10.1016/j.devcel.2020.12.017
Abstrakt:	A primary challenge in tissue engineering is to recapitulate both the structural and functional features of whole tissues and organs. In vivo, patterning of the body plan and constituent tissues emerges from the carefully orchestrated interactions between the transcriptional programs that give rise to cell types and the mechanical forces that drive the bending, twisting, and extensions critical to morphogenesis. Substantial recent progress in mechanobiology-understanding how mechanics regulate cell behaviors and what cellular machineries are responsible-raises the possibility that one can begin to use these insights to help guide the strategy and design of functional engineered tissues. In this perspective, we review and propose the development of different approaches, from providing appropriate extracellular mechanical cues to interfering with cellular mechanosensing machinery, to aid in controlling cell and tissue structure and function. Competing Interests: Declaration of Interests The authors declare no competing interests. (Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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