COVID-19 in pediatric kidney transplantation: The Improving Renal Outcomes Collaborative.

Autor: Varnell C Jr; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; University of Cincinnati College of Medicine, Cincinnati, Ohio., Harshman LA; University of Iowa Stead Family Children's Hospital, Iowa City, Iowa., Smith L; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Liu C; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Chen S; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Al-Akash S; Driscoll Children's Hospital, Corpus Christi, Texas., Barletta GM; Phoenix Children's Hospital, University of Arizona, Phoenix, Arizona., Belsha C; SSM Health Cardinal Glennon Children's Hospital, Saint Louis, Missouri., Brakeman P; Department of Pediatrics, University of California, San Francisco, California., Chaudhuri A; Lucile Packard Children's Hospital, Stanford University, Stanford, California., Fadakar P; UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania., Garro R; Children's Healthcare of Atlanta, Emory School of Medicine, Atlanta, Georgia., Gluck C; Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware., Goebel J; Children's Hospital Colorado, Aurora, Colorado., Kershaw D; C.S. Mott Children's Hospital, Ann Arbor, Michigan., Matossian D; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois., Nailescu C; Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana., Patel HP; Nationwide Children's Hospital, Columbus, Ohio., Pruette C; Johns Hopkins University School of Medicine, Baltimore, Maryland., Ranabothu S; Arkansas Children's Hospital, Little Rock, Arkansas., Rodig N; Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Smith J; Seattle Children's Hospital, Seattle, Washington., Sebestyen VanSickle J; Children's Mercy Kansas City, Kansas City, Missouri., Weng P; UCLA Mattel Children's Hospital, Los Angeles, California., Danziger-Isakov L; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; University of Cincinnati College of Medicine, Cincinnati, Ohio., Hooper DK; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.; University of Cincinnati College of Medicine, Cincinnati, Ohio., Seifert M; University of Alabama at Birmingham, Children's of Alabama, Birmingham, Alabama.
Jazyk: angličtina
Zdroj: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2021 Aug; Vol. 21 (8), pp. 2740-2748. Date of Electronic Publication: 2021 Feb 11.
DOI: 10.1111/ajt.16501
Abstrakt: There are limited data on the impact of COVID-19 in children with a kidney transplant (KT). We conducted a prospective cohort study through the Improving Renal Outcomes Collaborative (IROC) to collect clinical outcome data about COVID-19 in pediatric KT patients. Twenty-two IROC centers that care for 2732 patients submitted testing and outcomes data for 281 patients tested for SARS-CoV-2 by PCR. Testing indications included symptoms and/or potential exposures to COVID-19 (N = 134, 47.7%) and/or testing per hospital policy (N = 154, 54.8%). Overall, 24 (8.5%) patients tested positive, of which 15 (63%) were symptomatic. Of the COVID-19-positive patients, 16 were managed as outpatients, six received non-ICU inpatient care and two were admitted to the ICU. There were no episodes of respiratory failure, allograft loss, or death associated with COVID-19. To estimate incidence, subanalysis was performed for 13 centers that care for 1686 patients that submitted all negative and positive COVID-19 results. Of the 229 tested patients at these 13 centers, 10 (5 asymptomatic) patients tested positive, yielding an overall incidence of 0.6% and an incidence among tested patients of 4.4%. Pediatric KT patients in the United States had a low estimated incidence of COVID-19 disease and excellent short-term outcomes.
(© 2021 The American Society of Transplantation and the American Society of Transplant Surgeons.)
Databáze: MEDLINE
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