Impaired host response and the presence of Acinetobacter baumannii in the serum microbiome of type-II diabetic patients.
| Autor: | Perera D; The University of Rhode Island, Department of Cell and Molecular Biology, Kingston, RI 02881, USA., Kleinstein SE; J. Craig Venter Institute, La Jolla, CA 92037, USA., Hanson B; The University of Rhode Island, Department of Cell and Molecular Biology, Kingston, RI 02881, USA., Hasturk H; The Forsyth Institute, Cambridge, MA 02142, USA., Eveloff R; J. Craig Venter Institute, La Jolla, CA 92037, USA., Freire M; J. Craig Venter Institute, La Jolla, CA 92037, USA.; University of California San Diego, School of Medicine, La Jolla, CA 92093, USA., Ramsey M; The University of Rhode Island, Department of Cell and Molecular Biology, Kingston, RI 02881, USA. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | IScience [iScience] 2020 Dec 13; Vol. 24 (1), pp. 101941. Date of Electronic Publication: 2020 Dec 13 (Print Publication: 2021). |
| DOI: | 10.1016/j.isci.2020.101941 |
| Abstrakt: | Type II diabetes (T2D) affects over 10% of the US population and is a growing disease worldwide that manifests with numerous comorbidities and defects in inflammation. This dysbiotic host response allows for infection of the host by numerous microorganisms. In the course of T2D disease, individuals can develop chronic infections including foot ulcers and periodontitis, which lead to further complications and opportunistic infections in multiple body sites. In this study, we investigated the serum of healthy subjects and patients with T2D with (T2DP) or without periodontitis for both microbiome signatures in addition to cytokine profiles. Surprisingly, we detected the presence of Acinetobacter baumanii in the serum of 23% individuals with T2D/T2DP tested. In T2DP, IL-1β, TNF-α, MCP-1, IL-6, IL-8, and IFN-γ were significantly elevated in ABC-positive subjects. As an emerging pathogen, A. baumanii infection represents a risk for impaired inflammation and the development of comorbidities in subjects with T2D. Competing Interests: The authors declare no competing interests. (© 2020 The Authors.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|