Transdermal Delivery Systems for Biomolecules.

Autor: Peña-Juárez MC; Facultad de Estudios Superiores Cuautitlán-Universidad Nacional Autónoma de México, Unidad de Investigación Multidisciplinaria, Carretera Cuautitlán-Teoloyucan, km 2.5 San Sebastián Xhala, C.P. 54714 Cuautitlán Izcalli, México, Estado de México Mexico., Guadarrama-Escobar OR; Sección de Estudios de Posgrado e Investigación de la Escuela Nacional de Ciencias Biológicas. Programa de Posgrado: Doctorado en Ciencias Químico Biológicas-Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala s/n. Col. Santo Tomás C. P. 11340, Alcaldía Miguel Hidalgo, Ciudad de México, Mexico., Escobar-Chávez JJ; Facultad de Estudios Superiores Cuautitlán-Universidad Nacional Autónoma de México, Unidad de Investigación Multidisciplinaria, Carretera Cuautitlán-Teoloyucan, km 2.5 San Sebastián Xhala, C.P. 54714 Cuautitlán Izcalli, México, Estado de México Mexico.
Jazyk: angličtina
Zdroj: Journal of pharmaceutical innovation [J Pharm Innov] 2022; Vol. 17 (2), pp. 319-332. Date of Electronic Publication: 2021 Jan 06.
DOI: 10.1007/s12247-020-09525-2
Abstrakt: Purpose: The present review article focuses on highlighting the main technologies used as tools that improve the delivery of transdermal biomolecules, addressing them from the point of view of research in the development of transdermal systems that use physical and chemical permeation enhancers and nanocarrier systems or a combination of them.
Results: Transdermal drug delivery systems have increased in importance since the late 1970s when their use was approved by the Food and Drug Administration (FDA). They appeared to be an alternative resource for the administration of many potent drugs. The first transdermal drug delivery system used for biomolecules was for the treatment of hormonal disorders. Biomolecules have been used primarily in many treatments for cancer and diabetes, vaccines, hormonal disorders, and contraception.
Conclusions: The latest technologies that have used such transdermal biomolecule transporters include electrical methods (physical penetration enhancers), some chemical penetration enhancers and nanocarriers. All of them allow the maintenance of the physical and chemical properties of the main proteins and peptides through these clinical treatments, allowing their efficient storage, transport, and release and ensuring the achievement of their target and better results in the treatment of many diseases.
Competing Interests: Conflict of InterestThe authors declare no conflict of interest regarding the content and publication of this article.
(© The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021.)
Databáze: MEDLINE
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