Transmembrane redox regulation of genome replication functions in positive-strand RNA viruses.

Autor: Nishikiori M; John and Jeanne Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI 53715, United States; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706, United States., Ahlquist P; John and Jeanne Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI 53715, United States; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706, United States; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI 53706, United States; Howard Hughes Medical Institute, United States. Electronic address: ahlquist@wisc.edu.
Jazyk: angličtina
Zdroj: Current opinion in virology [Curr Opin Virol] 2021 Apr; Vol. 47, pp. 25-31. Date of Electronic Publication: 2020 Dec 28.
DOI: 10.1016/j.coviro.2020.12.003
Abstrakt: Positive-strand RNA virus genome replication takes place on intracellular membranes that separate the reduced cytosol from the oxidized extracellular/luminal milieu. Ongoing studies of these membrane-bounded genome replication complexes have revealed underlying common principles in their structure, assembly and functionalization, including transmembrane features and redox dependencies. Among these, members of the alphavirus, flavivirus, and picornavirus supergroups all encode membrane-permeabilizing viroporins required for efficient RNA replication. For flaviviruses and particularly alphavirus supergroup members, these viroporins are linked to activating viral RNA capping and potentially other later-stage RNA replication functions, and to local transmembrane release of oxidizing potential to trigger these changes in cytoplasmic RNA replication complexes. Further exploration of these emerging shared principles could spur development of broad-spectrum antivirals.
(Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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