MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat Pteropus alecto .

Autor:	Leeansyah E; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 14183 Stockholm, Sweden.; Precision Medicine and Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, 518055 Shenzhen, People's Republic of China., Hey YY; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Sia WR; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Ng JHJ; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Gulam MY; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Boulouis C; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 14183 Stockholm, Sweden., Zhu F; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Ahn M; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Mak JYW; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, The University of Queensland, Brisbane, QLD 4072, Australia., Fairlie DP; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, The University of Queensland, Brisbane, QLD 4072, Australia., Kwa ALH; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.; Department of Pharmacy, Singapore General Hospital, Singapore 169608, Singapore., Sandberg JK; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 14183 Stockholm, Sweden., Wang LF; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.; SingHealth Duke-NUS Global Health Institute, Singapore 169857, Singapore.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2020 Nov 28; Vol. 23 (12), pp. 101876. Date of Electronic Publication: 2020 Nov 28 (Print Publication: 2020).
DOI:	10.1016/j.isci.2020.101876
Abstrakt:	Bats are reservoirs for a large number of viruses which have potential to cause major human disease outbreaks, including the current coronavirus disease 2019 (COVID-19) pandemic. Major efforts are underway to understand bat immune response to viruses, whereas much less is known about their immune responses to bacteria. In this study, MR1-restricted T (MR1T) cells were detected through the use of MR1 tetramers in circulation and tissues of Pteropus alecto (Pa) bats. Pa MR1T cells exhibited weak responses to MR1-presented microbial metabolites at resting state. However, following priming with MR1-presented agonist they proliferated, upregulated critical transcription factors and cytolytic proteins, and gained transient expression of Th1/17-related cytokines and antibacterial cytotoxicity. Collectively, these findings show that the Pa bat immune system encompasses an abundant and functionally conserved population of MR1T cells with mucosal-associated invariant T-like characteristics, suggesting that MR1 and MR1T cells also play a significant role in bat immune defense. Competing Interests: D.P.F. is an inventor on a patent application (PCT/AU2013/000742, WO2014005194) and J.Y.W.M. and D.P.F. are inventors on another patent application (PCT/AU2015/050148, WO2015149130) involving MR1 ligands for MR1-restricted MAIT cells owned by University of Queensland, Monash University and University of Melbourne. The other authors declare no competing interests. (© 2020 The Author(s).)
Databáze:	MEDLINE
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