[Ultradian rhythms and oxidative stress in the tissue of the lymph nodes in ontogenesis.]

Autor:	Rozhkova IS; Astrakhan State Medical University, 121 Bakinskaya str., Astrakhan 414000; 2 Astrakhan State University, 20a Tatishcheva str., Astrakhan 414000, Russian Federation., Teply DL; Astrakhan State University, 20a Tatishcheva str., Astrakhan 414000, Russian Federation., Bazhanova ED; Astrakhan State University, 20a Tatishcheva str., Astrakhan 414000, Russian Federation.; Institite of Toxicology, Federal Medico-Biologocal Agency, 1 Bekhtereva str., St. Petersburg 192019, Russian Federation, e-mail: bazhanovae@mail.ru.; I.M.Sechenov Institute of Evolutionary Physiology and Biochemistry, 44 Thoreza pr., St. Petersburg 194223, Russian Federation.
Jazyk:	ruština
Zdroj:	Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2020; Vol. 33 (4), pp. 771-777.
Abstrakt:	We studied the age-related features of the ultradian rhythms of levels of total protein and albumin in the lymph nodes under normal condition and chronic toxic oxidative stress condition using the chronobiological approach and the biochemical methods. During the experiment, we compared the rhythmic activity of levels of total protein and albumin in the rat lymph nodes in ontogenesis and during chronic exposure to sulfur-containing natural gas. The revealed fluctuations of the levels of total protein and albumin can be characterized as around-hourly (ultradian) rhythms, which period is approximately 20-40 to 60 minutes. The obtained experimental data indicate a decrease in the adaptive resistance of lymph node with age and the depletion of the antioxidant system of rats in aging. These results could have a practical value for the development of correction methods of negative effects of toxic oxidative stress in ontogenesis.
Databáze:	MEDLINE
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