Alcohol dependence activates ventral tegmental area projections to central amygdala in male mice and rats.

Autor: Avegno EM; Departments of Physiology, Louisiana State University Health Science Center, New Orleans, Louisiana, USA.; Alcohol and Drug Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA., Kasten CR; Alcohol and Drug Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.; Cell Biology and Anatomy, Louisiana State University Health Science Center, New Orleans, Louisiana, USA., Snyder WB 3rd; Departments of Physiology, Louisiana State University Health Science Center, New Orleans, Louisiana, USA., Kelley LK; Departments of Physiology, Louisiana State University Health Science Center, New Orleans, Louisiana, USA., Lobell TD; Departments of Physiology, Louisiana State University Health Science Center, New Orleans, Louisiana, USA., Templeton TJ; Departments of Physiology, Louisiana State University Health Science Center, New Orleans, Louisiana, USA., Constans M; Departments of Physiology, Louisiana State University Health Science Center, New Orleans, Louisiana, USA., Wills TA; Alcohol and Drug Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.; Cell Biology and Anatomy, Louisiana State University Health Science Center, New Orleans, Louisiana, USA., Middleton JW; Alcohol and Drug Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.; Cell Biology and Anatomy, Louisiana State University Health Science Center, New Orleans, Louisiana, USA.; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA., Gilpin NW; Departments of Physiology, Louisiana State University Health Science Center, New Orleans, Louisiana, USA.; Alcohol and Drug Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.; Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.; Southeast Louisiana VA Healthcare System (SLVHCS), New Orleans, Louisiana, USA.
Jazyk: angličtina
Zdroj: Addiction biology [Addict Biol] 2021 Jul; Vol. 26 (4), pp. e12990. Date of Electronic Publication: 2020 Dec 16.
DOI: 10.1111/adb.12990
Abstrakt: The neural adaptations that occur during the transition to alcohol dependence are not entirely understood but may include a gradual recruitment of brain stress circuitry by mesolimbic reward circuitry that is activated during early stages of alcohol use. Here, we focused on dopaminergic and nondopaminergic projections from the ventral tegmental area (VTA), important for mediating acute alcohol reinforcement, to the central nucleus of the amygdala (CeA), important for alcohol dependence-related negative affect and escalated alcohol drinking. The VTA projects directly to the CeA, but the functional relevance of this circuit is not fully established. Therefore, we combined retrograde and anterograde tracing, anatomical, and electrophysiological experiments in mice and rats to demonstrate that the CeA receives input from both dopaminergic and nondopaminergic projection neurons primarily from the lateral VTA. We then used slice electrophysiology and fos immunohistochemistry to test the effects of alcohol dependence on activity and activation profiles of CeA-projecting neurons in the VTA. Our data indicate that alcohol dependence activates midbrain projections to the central amygdala, suggesting that VTA projections may trigger plasticity in the CeA during the transition to alcohol dependence and that this circuit may be involved in mediating behavioral dysregulation associated with alcohol dependence.
(© 2020 Society for the Study of Addiction.)
Databáze: MEDLINE
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