Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study.

Autor: Mat Ali MH; Endocrine Unit, Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, Malaysia., Tuan Ismail TS; Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, Malaysia.; Hospital Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia., Wan Azman WN; Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, Malaysia.; Hospital Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia., Yaacob NM; Hospital Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.; Department of Biostatistic, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, Malaysia., Yahaya N; Endocrine Unit, Department of Medicine, Hospital Raja Perempuan Zainab 2, Kota Bharu 15200, Kelantan, Malaysia., Draman N; Hospital Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.; Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, Malaysia., Wan Mohamed WMI; Endocrine Unit, Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, Malaysia.; Hospital Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia., Abdullah MS; Hospital Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.; Department of Diagnostic and Radiology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, Malaysia., Ibrahim HA; Hospital Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.; School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia., Wan Nik WNFH; Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, Malaysia.; Hospital Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia., Mohamed M; Endocrine Unit, Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian 16150, Kelantan, Malaysia.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2020 Dec 11; Vol. 10 (12). Date of Electronic Publication: 2020 Dec 11.
DOI: 10.3390/diagnostics10121075
Abstrakt: Thyroid hormones have a catabolic effect on bone homeostasis. Hence, this study aimed to evaluate serum vitamin D, calcium, and phosphate and bone marker levels and bone mineral density (BMD) among patients with different thyroid diseases. This cross-sectional study included patients with underlying thyroid diseases ( n = 64, hyperthyroid; n = 53 euthyroid; n = 18, hypothyroid) and healthy controls ( n = 64). BMD was assessed using z-score and left hip and lumbar bone density (g/cm 2 ). The results showed that the mean serum vitamin D Levels of all groups was low (<50 nmol/L). Thyroid patients had higher serum vitamin D levels than healthy controls. All groups had normal serum calcium and phosphate levels. The carboxy terminal collagen crosslink and procollagen type I N-terminal propeptide levels were high in hyperthyroid patients and low in hypothyroid patients. The z-score for hip and spine did not significantly differ between thyroid patients and control groups. The hip bone density was remarkably low in the hyperthyroid group. In conclusion, this study showed no correlation between serum 25(OH)D levels and thyroid diseases. The bone markers showed a difference between thyroid groups with no significant difference in BMD.
Databáze: MEDLINE
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