| Autor: |
Jiménez-Avalos JA; Unidad de Biotecnología Médica y Farmacéutica, Centro de Investigacón y Asistencia en Tecnología y Diseño del Estado de Jalisco (CIATEJ), Guadalajara, Jalisco, Mexico., Fernández-Macías JC; Coordinación para la Innovación y Aplicación de la Ciencia y Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico., González-Palomo AK; Coordinación para la Innovación y Aplicación de la Ciencia y Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico. karen.palomo@uaslp.mx.; Departamento de Ciencias Médicas, Campus León, Universidad de Guanajuato, Guanajuato, Mexico. karen.palomo@uaslp.mx. |
| Jazyk: |
angličtina |
| Zdroj: |
Molecular biology reports [Mol Biol Rep] 2021 Jan; Vol. 48 (1), pp. 961-967. Date of Electronic Publication: 2020 Dec 12. |
| DOI: |
10.1007/s11033-020-06050-w |
| Abstrakt: |
Exosomes are vesicles, ranging of 30-150 nm in diameter, which are released by different cell types into the extracellular space. Exosomes are capable of transporting several biomolecules such as proteins, lipids, DNA, mRNA, and non-coding RNA, including microRNAs (miRs). miRs signatures have been linked to the development of non-communicable diseases and their classification into various subtypes and/or stages. Interestingly, the miRs contained in exosomes (exomiRs) are suitable candidates as non-invasive biomarkers due to their stability in body fluids and harsh conditions, as well as they are considered critical players involved in intercellular communication; so that they can be a promising diagnostic tool for several diseases. Besides, exomiRs allow discrimination between different stages of the disease and could be a valuable strategy for the early detection of several pathologies in a non-invasive approach. This review aims to describe exomiRs present in biologic fluids that can be used as a tool for the diagnosis and prognosis of non-communicable diseases such as cancer, cardiovascular, kidney, and neurodegenerative disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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