[Intracellular pH measurement in glioblastoma cells: the possibilities of phosphorus-31 MR spectroscopy].

Autor:	Mertsalova MP; Burdenko Neurosurgical Center, Moscow, Russia., Pronin IN; Burdenko Neurosurgical Center, Moscow, Russia., Zakharova NE; Burdenko Neurosurgical Center, Moscow, Russia., Podoprigora AE; Burdenko Neurosurgical Center, Moscow, Russia., Batalov AI; Burdenko Neurosurgical Center, Moscow, Russia., Tyurina AN; Burdenko Neurosurgical Center, Moscow, Russia., Shults EI; Burdenko Neurosurgical Center, Moscow, Russia., Pogosbekyan EL; Burdenko Neurosurgical Center, Moscow, Russia., Fadeeva LM; Burdenko Neurosurgical Center, Moscow, Russia., Golanov AV; Burdenko Neurosurgical Center, Moscow, Russia., Postnov AA; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia., Rodionov PV; Burdenko Neurosurgical Center, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko [Zh Vopr Neirokhir Im N N Burdenko] 2020; Vol. 84 (6), pp. 26-32.
DOI:	10.17116/neiro20208406126
Abstrakt:	Objective: To analyze intracellular pH measurement with phosphorus-31 MR spectroscopy in glioblastoma cells and to compare these data with intracellular pH in healthy volunteers. Material and Methods: There were 10 patients aged 41 - 67 years with supratentorial glioblastomas. Intracellular pH in glioblastoma cells was compared with pH in healthy persons. Results: We found a tendency to increased intracellular pH in glioblastoma cells in comparison with pH in intact brain tissue. Conclusion: Intracellular pH in brain tissue can be used as a potential marker of early abnormalities which could not be detected by conventional MRI. Moreover, these data may be valuable to estimate the efficacy of chemotherapy. The study was supported by Russian Science Foundation (grant No. 18-15-00337).
Databáze:	MEDLINE
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