Functional respiratory imaging provides novel insights into the long-term respiratory sequelae of bronchopulmonary dysplasia.

Autor:	Vanhaverbeke K; Laboratory for Experimental Medicine and Paediatrics, University of Antwerp, Antwerp, Belgium kristien.vanhaverbeke@uantwerpen.be.; Dept of Paediatrics, Antwerp University Hospital, Edegem, Belgium., Slaats M; Laboratory for Experimental Medicine and Paediatrics, University of Antwerp, Antwerp, Belgium.; Dept of Paediatrics, Antwerp University Hospital, Edegem, Belgium., Al-Nejar M; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium., Everaars N; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium., Snoeckx A; Dept of Radiology, Antwerp University Hospital, Edegem, Belgium., Spinhoven M; Dept of Radiology, Antwerp University Hospital, Edegem, Belgium., El Addouli H; Dept of Radiology, Antwerp University Hospital, Edegem, Belgium., Lauwers E; Laboratory for Experimental Medicine and Paediatrics, University of Antwerp, Antwerp, Belgium.; Dept of Paediatrics, Antwerp University Hospital, Edegem, Belgium., Van Eyck A; Laboratory for Experimental Medicine and Paediatrics, University of Antwerp, Antwerp, Belgium.; Dept of Paediatrics, Antwerp University Hospital, Edegem, Belgium., De Winter BY; Laboratory for Experimental Medicine and Paediatrics, University of Antwerp, Antwerp, Belgium.; Dept of Gastro-enterology and Hepatology, Antwerp University Hospital, Edegem, Belgium., Van Hoorenbeeck K; Laboratory for Experimental Medicine and Paediatrics, University of Antwerp, Antwerp, Belgium.; Dept of Paediatrics, Antwerp University Hospital, Edegem, Belgium., De Dooy J; Laboratory for Experimental Medicine and Paediatrics, University of Antwerp, Antwerp, Belgium.; Paediatric Intensive Care Unit, Antwerp University Hospital, Edegem, Belgium., Mahieu L; Laboratory for Experimental Medicine and Paediatrics, University of Antwerp, Antwerp, Belgium.; Neonatal Intensive Care Unit, Antwerp University Hospital, Edegem, Belgium., Mignot B; Fluidda, Kontich, Belgium., De Backer J; Fluidda, Kontich, Belgium., Mulder A; Laboratory for Experimental Medicine and Paediatrics, University of Antwerp, Antwerp, Belgium.; Neonatal Intensive Care Unit, Antwerp University Hospital, Edegem, Belgium., Verhulst S; Laboratory for Experimental Medicine and Paediatrics, University of Antwerp, Antwerp, Belgium.; Dept of Paediatrics, Antwerp University Hospital, Edegem, Belgium.
Jazyk:	angličtina
Zdroj:	The European respiratory journal [Eur Respir J] 2021 Jun 04; Vol. 57 (6). Date of Electronic Publication: 2021 Jun 04 (Print Publication: 2021).
DOI:	10.1183/13993003.02110-2020
Abstrakt:	Rationale: Bronchopulmonary dysplasia (BPD) is a common complication of preterm birth. Lung function and imaging are classically used to assess BPD. Functional respiratory imaging (FRI) combines a structural and functional assessment of the airways and their vasculature. We aimed to assess BPD using FRI and to correlate these findings with the clinical presentation. Methods: We included 37 adolescents with a history of preterm birth (22 BPD cases and 15 preterm controls). The study protocol included a detailed history, lung function testing and computed tomography (CT) (at total lung capacity (TLC) and functional residual capacity (FRC)) with FRI. CT images were also assessed using the Aukland scoring system. Results: BPD patients had lower forced expiratory volume in 1 s to forced vital capacity ratio (p=0.02) and impaired diffusion capacity (p=0.02). Aukland CT scores were not different between the two groups. FRI analysis showed higher lobar volumes in BPD patients at FRC (p<0.01), but not at TLC. Airway resistance was significantly higher in the BPD group, especially in the distal airways. Additionally, FRI showed more air trapping in BPD patients, in contrast to findings on conventional CT images. Conclusion: This study is the first to use FRI in research for BPD. FRI analysis showed higher lobar volumes in BPD patients, indicating air trapping and reduced inspiratory capacity. In contrast to Aukland CT scores, FRI showed more air trapping in the BPD group, suggesting that FRI might be a more sensitive detection method. Importantly, we also showed increased distal airway resistance in BPD patients. By combining structural and functional assessment, FRI may help to better understand the long-term sequelae of BPD. Competing Interests: Conflict of interest: K. Vanhaverbeke has nothing to disclose. Conflict of interest: M. Slaats has nothing to disclose. Conflict of interest: M. Al-Nejar has nothing to disclose. Conflict of interest: N. Everaars has nothing to disclose. Conflict of interest: A. Snoeckx has nothing to disclose. Conflict of interest: M. Spinhoven has nothing to disclose. Conflict of interest: H. El Addouli has nothing to disclose. Conflict of interest: E. Lauwers has nothing to disclose. Conflict of interest: A. Van Eyck has nothing to disclose. Conflict of interest: B.Y. De Winter has nothing to disclose. Conflict of interest: K. Van Hoorenbeeck has nothing to disclose. Conflict of interest: J. De Dooy has nothing to disclose. Conflict of interest: L. Mahieu has nothing to disclose. Conflict of interest: B. Mignot is an employee of Fluidda. Conflict of interest: J. De Backer is an employee/shareholder of Fluidda. Conflict of interest: A. Mulder has nothing to disclose. Conflict of interest: S. Verhulst reports grants from Vitalaire Belgium and Josephine Neiman Foundation, during the conduct of the study. (Copyright ©ERS 2021. For reproduction rights and permissions contact permissions@ersnet.org.)
Databáze:	MEDLINE
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