Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroprevalence in healthcare personnel in northern California early in the coronavirus disease 2019 (COVID-19) pandemic.

Autor:	Rosser JI; Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California., Röltgen K; Department of Pathology, Stanford University School of Medicine, Stanford, California., Dymock M; Stanford Health Care, Stanford, California., Shepard J; Stanford Health Care, Stanford, California., Martin A; Stanford Health Care, Stanford, California., Hogan CA; Department of Pathology, Stanford University School of Medicine, Stanford, California., Blomkalns A; Department of Emergency Medicine, Stanford University School of Medicine, Stanford, California., Mathew R; Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California., Parsonnet J; Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California., Pinsky BA; Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.; Department of Pathology, Stanford University School of Medicine, Stanford, California., Maldonado YA; Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford, California., Boyd SD; Department of Pathology, Stanford University School of Medicine, Stanford, California., Chang SI; Stanford Health Care, Stanford, California., Holubar M; Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.; Stanford Health Care, Stanford, California.
Jazyk:	angličtina
Zdroj:	Infection control and hospital epidemiology [Infect Control Hosp Epidemiol] 2021 Sep; Vol. 42 (9), pp. 1053-1059. Date of Electronic Publication: 2020 Dec 09.
DOI:	10.1017/ice.2020.1358
Abstrakt:	Objective: We assessed the magnitude of unidentified coronavirus disease 2019 (COVID-19) in our healthcare personnel (HCP) early in the COVID-19 pandemic, and we evaluated risk factors for infection to identify areas for improvement in infection control practice in a northern California academic medical center. Methods: We reviewed anti-severe acute respiratory coronavirus virus 2 (SARS-CoV-2) receptor-binding domain (RBD) IgG serologic test results and self-reported risk factors for seropositivity among 10,449 asymptomatic HCP who underwent voluntary serology testing between April 20 and May 20, 2020. Results: In total, 136 employees (1.3%) tested positive for SARS-CoV-2 IgG. This included 41 individuals (30.1%) who had previously tested positive for SARS-CoV-2 by nasopharyngeal reverse-transcription polymerase chain reaction (RT-PCR) between March 13 and April 16, 2020. In multivariable analysis, employees of Hispanic ethnicity (odds ratio [OR], 2.01; 95% confidence interval [CI], 1.22-3.46) and those working in environmental services, food services, or patient transport (OR, 4.81; 95% CI, 2.08-10.30) were at increased risk for seropositivity compared to other groups. Employees reporting a household contact with COVID-19 were also at higher risk for seropositivity (OR, 3.25; 95% CI, 1.47-6.44), but those with a work, exposure alone were not (OR, 1.27; 95% CI, 0.58-2.47). Importantly, one-third of seropositive individuals reported no prior symptoms, no suspected exposures, and no prior positive RT-PCR test. Conclusion: In this study, SARS-CoV-2 seropositivity among HCP early in the northern California epidemic appeared to be quite low and was more likely attributable to community rather than occupational exposure.
Databáze:	MEDLINE
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