Increased leukotriene B4 plasma concentration in type 2 diabetes individuals with cardiovascular autonomic neuropathy.

Autor: Neves JAJ; Programa de Pos-Graduação Em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, 2° subsolo, Pos-graduação, Sao Paulo, CEP: 01504-001, Brazil., De Matos MR; Programa de Pos-Graduação Em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, 2° subsolo, Pos-graduação, Sao Paulo, CEP: 01504-001, Brazil.; Unidade Básica de Saúde Dra. Ilza Weltman Hutzler. Rua Coronel Walfrido de Carvalho, Sao Paulo, CEP: 02472-180, Brazil., Ramalho T; Laboratório de Imunofarmacologia, Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes, 1730, Sao Paulo, CEP: 05508-900, Brazil., Santos-Bezerra DP; Laboratório de Carboidratos E Radioimunoensaio (LIM-18) Do Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Avenida Dr. Arnaldo, 455, Sala 3321, Sao Paulo, CEP: 01246-903, Brazil., Cavalcante CDGD; Unidade Básica de Saúde Dra. Ilza Weltman Hutzler. Rua Coronel Walfrido de Carvalho, Sao Paulo, CEP: 02472-180, Brazil., Alpino Peixoto R; Programa de Pos-Graduação Em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, 2° subsolo, Pos-graduação, Sao Paulo, CEP: 01504-001, Brazil., Queiroz MS; Programa de Pos-Graduação Em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, 2° subsolo, Pos-graduação, Sao Paulo, CEP: 01504-001, Brazil., Jancar S; Laboratório de Imunofarmacologia, Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes, 1730, Sao Paulo, CEP: 05508-900, Brazil., Correa-Giannella ML; Programa de Pos-Graduação Em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, 2° subsolo, Pos-graduação, Sao Paulo, CEP: 01504-001, Brazil. m.giannella@uni9.pro.br.; Laboratório de Carboidratos E Radioimunoensaio (LIM-18) Do Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Avenida Dr. Arnaldo, 455, Sala 3321, Sao Paulo, CEP: 01246-903, Brazil. m.giannella@uni9.pro.br.
Jazyk: angličtina
Zdroj: Diabetology & metabolic syndrome [Diabetol Metab Syndr] 2020 Nov 12; Vol. 12 (1), pp. 99. Date of Electronic Publication: 2020 Nov 12.
DOI: 10.1186/s13098-020-00606-3
Abstrakt: Background and Aim: A low-grade inflammation is associated with cardiac autonomic neuropathy (CAN) and increased concentration of leukotriene B4 (LTB4) was found in individuals with type 1 diabetes and definitive CAN. This cross-sectional study evaluated plasma concentration of LTB4 and of other inflammatory mediators, namely, tumor necrosis factor (TNF), interleukin (IL)1B, and IL10 in individuals with type 2 diabetes (T2D) and different degrees of CAN, and correlated these inflammatory mediators with the degree of glycemic control and with a surrogate marker of insulin resistance.
Methods: TNF, IL1B, IL10 and LTB4 plasma concentrations were measured in 129 T2D subjects (62% women with [median] age of 63 years, disease duration of 8 years and HbA1c of 7.3%) with or without CAN. The Lipid accumulation product index was used as a surrogate marker of insulin resistance.
Results: LTB4 concentration was significantly higher in those presenting incipient CAN (69.7 ± 16.6 pg mL -1 ) and definitive CAN (71.5 ± 15.7 pg mL -1 ) versus those without CAN (57.0 ± 13.9 pg mL -1 ). The groups without CAN and with incipient CAN were pooled (group without definitive CAN) and compared to those with definitive CAN. LTB4 concentration was higher in the latter group, as well as TNF concentration, while IL10 concentration was lower in this group. After adjustment for confounding variables, only LTB4 concentration remained significantly different between the groups with and without definitive CAN. Plasma concentration of LTB4 did not correlate with the degree of glycemic control. After sorting the participants by sex, a borderline weak correlation was found between LTB4 and the Lipid accumulation product index in women.
Conclusion: In the T2D setting, circulating LTB4 concentration seems to be associated with cardiovascular dysautonomia.
Databáze: MEDLINE
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