| Autor: |
Yang CY; Institute for Regenerative Medicine and Biomimetic Materials, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China., Huang WY, Chen LH, Liang NW, Wang HC, Lu J, Wang X, Wang TW |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of materials chemistry. B [J Mater Chem B] 2021 Jan 28; Vol. 9 (3), pp. 567-584. |
| DOI: |
10.1039/d0tb01605e |
| Abstrakt: |
During nervous system development, an extracellular matrix (ECM) plays a pivotal role through surface topography and microenvironment signals in neurons and neurites maturation. Topography and microenvironment signals act as physical and chemical guiding cues, respectively, for neural tissue formation and reconstruction. Imposed surface topography can affect neural stem cells by promoting adhesion, spreading, alignment, morphological changes, and specific gene expression. Therefore, fabrication of a biomimetic construct or scaffold to support neurite outgrowth and axon extension is a crucial and common strategy for neural tissue regeneration. Here, we review recent developments in biomaterials modification for simulating the microenvironment to promote neural cell adhesion and growth. The subtopics include those of potential cellular mechanisms of topographical response, topography on cellular organization and function, contact guidance in neurite outgrowth and axon growth, ECM microenvironment as regulatory cues, as well as challenges and future perspectives of nerve conduits that are now in clinical trials and usage. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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