Curcumin mitigates neurotoxic and neurobehavioral changes of gentamicin and sodium salicylate in rats by adjusting oxidative stress and apoptosis.

Autor: Abd-Elhakim YM; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt. Electronic address: yasmina_forensic@hotmail.com., Abdel-Motal SM; Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Malhat SM; Animal Health Research Institute, Zagazig, Egypt., Mostafa HI; Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Moselhy AAA; Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Zagazig University, Egypt., Beheiry RR; Department of Histology and Cytology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt., Said EN; Department of Veterinary Public Health, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2021 Jan 15; Vol. 265, pp. 118824. Date of Electronic Publication: 2020 Dec 02.
DOI: 10.1016/j.lfs.2020.118824
Abstrakt: Currently, antibiotics and salicylates are the most highly consumed medications worldwide. The side effects of these pharmaceuticals on the nervous system have been little investigated. Thus, this study aimed to examine the influence of the gentamicin (GM) and sodium salicylates (SS) on neurobehavioral functions, including locomotors function, memory, and sensorimotor functions together with gamma-aminobutyric acid (GABA) neurotransmitter levels. Also, oxidative stress, lipid peroxidation, and apoptotic indicators of brain tissue were assessed. Additionally, the histopathological architecture of brain tissues was investigated. This study also evaluated the curcumin (CUR) efficacy to counteract the GM or SS induced neurotoxic impacts in rats. For this purpose, seven groups were administered physiological saline (1 ml/rat; orally), olive oil (1 ml/rat; orally), CUR (50 mg/kg bwt; orally), GM (120 mg/kg bwt; intraperitoneally), SS (300 mg /kg bwt; intraperitoneally), CUR + GM, or CUR + SS for consecutive 15 days. The results revealed that GM and SS exposure evoked impaired memory, sensorimotor deficit functions, and depressive-like behavior together with the depletion of GABA. GM and SS exposure elevated malondialdehyde and Caspase-3 levels, but total antioxidant capacity and Bcl-2 levels were reduced. Besides, GM and SS exposure induced distinct pathological perturbations in cerebral cortices and hippocampus tissues. CUR significantly reversed the GM and SS harmful impacts. In conclusion, these findings verified that CUR could be a biologically efficient protective intervention against GM and SS induced neurotoxic impacts and neurobehavioral aberrations.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: