Late Oral Complications Caused by Head and Neck Radiotherapy: Clinical and Laboratory Study.

Autor:	Martinez AC; School of Biological Sciences and Healthcare, Department of Dentristry, Western Paraná State University, CascavelBrazil., Silva IMV; School of Life Sciences, Department of Dentristry, Pontifícia Universidade Católica do Paraná, CuritibaBrazil., Berti Couto SA; School of Life Sciences, Department of Dentristry, Pontifícia Universidade Católica do Paraná, CuritibaBrazil., Gandra RF; School of Pharmaceutical Sciences and Medicine, Department of Pharmaceutical Sciences, Western Paraná State University, CascavelBrazil., Rosa EAR; School of Life Sciences, Department of Dentristry, Pontifícia Universidade Católica do Paraná, CuritibaBrazil., Johann ACBR; School of Life Sciences, Department of Dentristry, Pontifícia Universidade Católica do Paraná, CuritibaBrazil., Couto Souza PH; School of Life Sciences, Department of Dentristry, Pontifícia Universidade Católica do Paraná, CuritibaBrazil.
Jazyk:	angličtina
Zdroj:	Journal of oral & maxillofacial research [J Oral Maxillofac Res] 2020 Nov 30; Vol. 11 (3), pp. e3. Date of Electronic Publication: 2020 Nov 30 (Print Publication: 2020).
DOI:	10.5037/jomr.2020.11303
Abstrakt:	Objectives: The aim of presented cross-sectional and observational study was to determine the prevalence of late oral complications of patients with head and neck cancer who underwent radiotherapy, by clinical and laboratory analyses. Material and Methods: Fifty-five patients, 43 (78.2%) men and 12 (21.8%) women, mean age 60; range 38 to 87 years, who have completed radiotherapy for head and neck cancer for at least 6 months were enrolled. The presence of xerostomia, hyposalivation, oral candidiasis, and type of oral yeasts were correlated with post-radiotherapy period. A control group, age and gender matched, was used for comparisons. The Pearson's Chi-square or Fischer's exact test was used at a significance level of 5%. Results: The mean post-radiotherapy period was 32 months. The oral complications found were xerostomia (45/55, [81.8%]), hyposalivation (44/55 [80%]) and oral candidiasis (15/55 [27.2%]). Xerostomia and hyposalivation was statistically higher in the study group when compared to the control group (P < 0.05). The presence of yeast occurred in 39 (70.9%) of the patients in the study group, and Candida albicans was the most prevalent etiological agent in 25 (64.1%) of those patients (P < 0.05). Conclusions: Xerostomia and hyposalivation were the more prevalent late oral complications related to radiotherapy. Oral candidiasis was also observed, although its prevalence was lower. The need for long-term dental follow-up of patients who underwent radiotherapy of the head and neck cancer is mandatory. (Copyright © Martinez AC, Silva IMV, Berti Couto SA, Gandra RF, Rosa EAR, Johann ACBR, Couto Souza PH. Published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH (http://www.ejomr.org), 30 September 2020.)
Databáze:	MEDLINE
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