| Autor: |
Soysal A; Memorial Ataşehir Hospital, Division of Pediatric Infectious Diseases, Turkey., Gönüllü E; Memorial Ataşehir Hospital, Division of Pediatric Infectious Diseases, Turkey., Arslan H; Medipol University, Department of Pediatrics, Turkey., Kibar BS; Yalova State Hospital, Turkey., Pop S; Erbaa State Hospital, Turkey., Yurttaş GN; Tokat State Hospital, Turkey., Demirbacak H; Yalova State Hospital, Turkey., Ünal F; Medipol University, Department of Pediatrics, Turkey., Öktem S; Medipol University, Department of Pediatrics, Turkey., Atıcı S; Okan University Hospital, Division of Pediatric Infectious Diseases, Turkey., Yücel Şen AD; Yalova State Hospital, Turkey., Karabayır N; Medipol University, Department of Pediatrics, Turkey., Karaböcüoğlu M; Memorial Ataşehir Hospital, Division of Pediatric Infectious Diseases, Turkey. |
| Jazyk: |
angličtina |
| Zdroj: |
Japanese journal of infectious diseases [Jpn J Infect Dis] 2021 Jul 21; Vol. 74 (4), pp. 273-279. Date of Electronic Publication: 2020 Dec 01. |
| DOI: |
10.7883/yoken.JJID.2020.781 |
| Abstrakt: |
Little is known about the therapeutic use of hydroxychloroquine in pediatric patients with coronavirus disease 2019 (COVID-19). Here, we retrospectively retrieved data of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) PCR-positive pediatric patients from 20 hospitals in 8 Turkish cities. We obtained epidemiological, clinical, and laboratory features of the patients, as well as the drugs used for treating COVID-19. A total of 237 nasopharyngeal swab SARS-CoV-2 PCR-positive children were included in the study from March 26, 2020 to June 20, 2020. The mean age of asymptomatic children (118 ± 62 months) was higher than that of symptomatic children (89 ± 69 months). Symptomatic children had significantly lower mean lymphocyte counts and higher mean CRP, D-dimer, procalcitonin, and LDH levels than asymptomatic children in the univariate analysis. Among 156 children, 78 (50%), 15, 44, and 21 were treated with a hydroxychloroquine-containing regimen, hydroxychloroquine + azithromycin + oseltamivir, hydroxychloroquine + azithromycin, and hydroxychloroquine alone, respectively. Among 156 patients who received medical treatment, 90 (58%) underwent pre- and/or post-treatment electrocardiogram (ECG). However, none of them had ECG abnormalities or required hydroxychloroquine discontinuation due to adverse drug reactions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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