Anti-inflammatory, hypoglycemic, hypolipidemic, and analgesic activities of Plinia cauliflora (Mart.) Kausel (Brazilian grape) epicarp.

Autor: Brito TGDS; Laboratório de Lipídios e Aplicações de Biomoléculas em Doenças Prevalentes e Negligenciadas. Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, 1235, CEP 50670-901, Recife, PE, Brazil., Silva APSD; Laboratório de Lipídios e Aplicações de Biomoléculas em Doenças Prevalentes e Negligenciadas. Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, 1235, CEP 50670-901, Recife, PE, Brazil., Cunha RXD; Laboratório de Lipídios e Aplicações de Biomoléculas em Doenças Prevalentes e Negligenciadas. Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, 1235, CEP 50670-901, Recife, PE, Brazil., Fonseca CSMD; Laboratório de Lipídios e Aplicações de Biomoléculas em Doenças Prevalentes e Negligenciadas. Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, 1235, CEP 50670-901, Recife, PE, Brazil. Electronic address: caiquesmfonseca@gmail.com., Araújo TFDS; Colegiado de Ciências Farmacêuticas, Universidade Federal do Vale Eo São Francisco, Avenida José de Sá Maniçoba, S/N, CEP 56304917, Petrolina, PE, Brazil., Campos JKL; Laboratório Morfofuncional, Curso de Medicina, Núcleo de Ciências da Vida, Centro Acadêmico do Agreste, Universidade Federal de Pernambuco, Rodovia BR-104, Km 62, S/N, CEP, 55014-908, Caruaru, PE, Brazil., Nascimento WM; Laboratório de Lipídios e Aplicações de Biomoléculas em Doenças Prevalentes e Negligenciadas. Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, 1235, CEP 50670-901, Recife, PE, Brazil., Araújo HDA; Laboratório de Lipídios e Aplicações de Biomoléculas em Doenças Prevalentes e Negligenciadas. Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, 1235, CEP 50670-901, Recife, PE, Brazil., Silva JPRE; Laboratório Multiusuário de Caracterização e Análise - LMCA, Universidade Federal da Paraíba, Cidade Universitária, Campus I, Castelo Branco III, S/N, 58033-455, João Pessoa, PB, Brazil., Tavares JF; Laboratório Multiusuário de Caracterização e Análise - LMCA, Universidade Federal da Paraíba, Cidade Universitária, Campus I, Castelo Branco III, S/N, 58033-455, João Pessoa, PB, Brazil., Santos BSD; Laboratório Morfofuncional, Curso de Medicina, Núcleo de Ciências da Vida, Centro Acadêmico do Agreste, Universidade Federal de Pernambuco, Rodovia BR-104, Km 62, S/N, CEP, 55014-908, Caruaru, PE, Brazil., Lima VLM; Laboratório de Lipídios e Aplicações de Biomoléculas em Doenças Prevalentes e Negligenciadas. Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, 1235, CEP 50670-901, Recife, PE, Brazil. Electronic address: lima.vera.ufpe@gmail.com.
Jazyk: angličtina
Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 25; Vol. 268, pp. 113611. Date of Electronic Publication: 2020 Nov 23.
DOI: 10.1016/j.jep.2020.113611
Abstrakt: Ethnopharmacological Relevance: Plinia cauliflora (Mart.) Kausel, known in Brazil as jabuticaba or jaboticaba has been used by Brazilian native populations for medicinal purposes, including those related to inflammatory conditions, such as asthma, diarrhea, disorders in female genitourinary tract, and tonsillitis. Inflammation has emerged as a main factor for the oxidative stress, hyperglycemia, and dyslipidemia present in chronic noncommunicable diseases (NCDs). Such disturbances have been a leading cause of death worldwide for decades, despite significant efforts in developing new therapies. Therefore, strengthening the relevance of ethnobotanic approaches, as P. cauliflora has the potential to become a natural, native, and traditional product to prevent and treat inflammation-associated diseases more effectively for more people.
Aim of the Study: Evaluate anti-inflammatory, hypoglycemic, hypolipidemic, and analgesic properties of hydroethanolic extract of P. cauliflora epicarps (PcE).
Materials and Methods: Phytochemical compound from the PcE were identified through HPLC-DAD-ESI-MS n analysis. Antioxidant activity was determined by measuring 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging. The anti-inflammatory potential was investigated by carrageenan-induced paw edema and peritonitis in mice. Analgesic effect was assessed, in mice, though hot plate test and acetic acid-induced abdominal writhing. Antidiabetic and hypolipidemic potential were evaluated using alloxan-induced diabetic mice.
Results: Tannins, phenolic acids, and their derivatives were the predominant phytochemicals found. Overall, PcE showed different properties related to the treatment of clinical conditions associated with chronic diseases as a potent antioxidant activity, demonstrating a radical scavenging action similar to gallic acid. PcE oral administration also significantly reduced inflammation induced by paw edema and partially blocked leukocyte migration. Moreover, PcE produced peripheral and central analgesic effects, as evaluated in the writhing model and hot plate tests. Treatment with PcE significantly improved glucose levels and lipid markers in diabetic mice.
Conclusions: P. cauliflora fruits are rich sources of secondary metabolites, mainly tannins and phenolic acids with high biological potential, which can effectively contribute to the approach of preventing and controlling chronic NCDs.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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