Effects of homologous and heterologous rich platelets plasma, compared to poor platelets plasma, on cutaneous healing of rabbits.

Autor:	Meira RO; Fellow PhD degree, Graduate Program in Pathology, Universidade Federal de Minas Gerais (UFMG), and Instituto de Ensino e Pesquisa (IEP), Santa Casa de Belo Horizonte, Brazil. Conception and design of the study; acquisition, analysis and interpretation of data; manuscript preparation and writing., Braga DNM; Graduate student, Department of Surgery, Medical School, UFMG, Belo Horizonte-MG, Brazil. Technical procedures, acquisition of data, manuscript preparation and writing., Pinheiro LSG; Fellow PhD degree, Teaching and Research Institute, IEP, Belo Horizonte-MG, Brazil. Technical procedures, acquisition of data., Amorim IFG; Full Professor, Department of Pathology, Faculdade de Minas (FAMINAS), Belo Horizonte-MG, Brazil. Histopathological examinations., Vasconcellos LS; Associate Professor, Department of Clinical Pathology, Medical School, UFMG, Belo Horizonte-MG, Brazil. Substantive scientific and intellectual contributions to the study, technical procedures, critical revision, final approval., Alberti LR; Associate Professor, Department of Surgery, Medical School, UFMG and IEP, Belo Horizonte-MG, Brazil. Substantive scientific and intellectual contributions to the study, conception and design, final approval.
Jazyk:	angličtina
Zdroj:	Acta cirurgica brasileira [Acta Cir Bras] 2020 Nov 23; Vol. 35 (10), pp. e202001006. Date of Electronic Publication: 2020 Nov 23 (Print Publication: 2020).
DOI:	10.1590/s0102-865020200100000006
Abstrakt:	Purpose: To evaluate and compare the effects of homologous and heterologous PRP (Platelet-Rich Plasma) on the quality and speed of skin wound healing, compared to Poor Platelet Plasma (PPP). Methods: Twenty-one male adult rabbits were used; two for preparing homologous PRP, with the rest of them separated randomly in three groups, according to the treatment received: PPP - control (n=5), homologous PRP (n=7), heterologous (n=7). Excisional skin wounds were made on the back of the animals, for the application of homologous and heterologous PPP and PRP. At the 14th post-operative day (POD), the animals were subjected to a new wound, and the treatments were inverted. The wounds were evaluated macroscopically and histologically. Results: A larger percentage of scar retraction was observed on the group treated with heterologous PRP, compared to homologous PRP, at the third POD, an increase of 25.03% (p=0.01). No other statistically significant differences among treatments were observed. Among every group, skin healing was efficient, without local adverse effects. Conclusions: Heterologous PRP contributed with more tissue retraction at the beginning of the wound healing process. After this, there were no differences on the wound healing skin process treated with PRP or PPP. However, our findings suggest the presence of others plasmatic factors, besides platelets, which could also contribute to the wound healing process, and thus, should be further investigated.
Databáze:	MEDLINE
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