Convalescent plasma therapy and remdesivir duo successfully salvaged an early liver transplant recipient with severe COVID-19 pneumonia.

Autor: Jamir I; Department of HPB Surgery and Liver Transplantation, B. L. Kapoor Super Speciality Hospital, New Delhi, India., Lohia P; Department of HPB Surgery and Liver Transplantation, B. L. Kapoor Super Speciality Hospital, New Delhi, India., Pande RK; Department of Critical Care, B. L. Kapoor Super Speciality Hospital, New Delhi, India., Setia R; Department of Transfusion Medicine, B. L. Kapoor Super Speciality Hospital, New Delhi, India., Singhal AK; Department of Liver Transplant & HPB Anaesthesia, B. L. Kapoor Super Speciality Hospital, New Delhi, India., Chaudhary A; Department of HPB Surgery and Liver Transplantation, B. L. Kapoor Super Speciality Hospital, New Delhi, India.
Jazyk: angličtina
Zdroj: Annals of hepato-biliary-pancreatic surgery [Ann Hepatobiliary Pancreat Surg] 2020 Nov 30; Vol. 24 (4), pp. 526-532.
DOI: 10.14701/ahbps.2020.24.4.526
Abstrakt: The impact and clinical spectrum of COVID-19 infection in liver transplant recipients/solid organ transplants are being unveiled during this recent pandemic. The clinical experience of use of current antiviral drugs and immunomodulators are sparse in solid organ transplantation. We present the clinical course of a 49-year-old male recipient who underwent living donor liver transplant for recurrent gastrointestinal bleed and contracted severe COVID-19 pneumonia during the third postoperative week. Herein we report the successful management of severe COVID-19 pneumonia using convalescent plasma therapy and remdesivir. Recipient's clinical deterioration was halted after three consecutive convalescent plasma transfusions with improvement in hypoxia and inflammatory markers (interleukin-6 and C-reactive protein). The use of convalescent plasma therapy along with remdesivir may be an ideal combination in the management of severe COVID-19 pneumonia in solid organ transplant recipients.
Databáze: MEDLINE
Externí odkaz: