(-)-Camphene-based derivatives as potential antibacterial agents against Staphylococcus aureus and Enterococcus spp.

Autor: de Freitas BC; Postgraduate Program in Bioscience & Physiopathology, State University of Maringa, Parana 87020 900, Brazil., Queiroz PA; Postgraduate Program in Bioscience & Physiopathology, State University of Maringa, Parana 87020 900, Brazil., Baldin VP; Postgraduate Program in Bioscience & Physiopathology, State University of Maringa, Parana 87020 900, Brazil., do Amaral PH; Department of Clinical Analysis & Biomedicine, Laboratory of Medical Bacteriology, State University of Maringa, Parana 87020 900, Brazil., Rodrigues LL; Department of Chemistry, Federal Technological University of Parana, Londrina, Parana 86036 370, Brazil., Vandresen F; Department of Chemistry, Federal Technological University of Parana, Londrina, Parana 86036 370, Brazil., R Caleffi-Ferracioli K; Postgraduate Program in Bioscience & Physiopathology, State University of Maringa, Parana 87020 900, Brazil.; Department of Clinical Analysis & Biomedicine, Laboratory of Medical Bacteriology, State University of Maringa, Parana 87020 900, Brazil., de L Scodro RB; Department of Clinical Analysis & Biomedicine, Laboratory of Medical Bacteriology, State University of Maringa, Parana 87020 900, Brazil.; Postgraduate Program in Health Sciences, State University of Maringa, Parana 87020 900, Brazil., Cardoso RF; Postgraduate Program in Bioscience & Physiopathology, State University of Maringa, Parana 87020 900, Brazil.; Department of Clinical Analysis & Biomedicine, Laboratory of Medical Bacteriology, State University of Maringa, Parana 87020 900, Brazil.; Postgraduate Program in Health Sciences, State University of Maringa, Parana 87020 900, Brazil., Siqueira VL; Postgraduate Program in Bioscience & Physiopathology, State University of Maringa, Parana 87020 900, Brazil.; Department of Clinical Analysis & Biomedicine, Laboratory of Medical Bacteriology, State University of Maringa, Parana 87020 900, Brazil.
Jazyk: angličtina
Zdroj: Future microbiology [Future Microbiol] 2020 Oct; Vol. 15, pp. 1527-1534. Date of Electronic Publication: 2020 Nov 20.
DOI: 10.2217/fmb-2020-0131
Abstrakt: Aim: To evaluate the activity of (-)-camphene-based thiosemicarbazide (TSC) and 4-hydroxy-thiosemicarbazone (4-OH-TSZ), alone and in combination against Gram-positive. Material & methods: MIC were determined for Staphylococcus aureus , Enterococcus spp. reference strains and clinical isolates. Drug combination, time-kill and cytotoxicity assays were also performed. Results: TSC and 4-OH-TSZ demonstrated potent inhibitory activity against S. aureus and Enterococcus spp., including multidrug-resistant isolates (MIC ranging from 1.9 to 31.2 μg/ml), and were bactericidal for the reference strains of both Gram-positive tested. The derivatives proved to be selective for the bacteria and synergistic with oxacillin and vancomycin. Conclusion: (-)-Camphene-based derivatives can represent promising drug candidates against critical pathogens, such as S. aureus and Enterococcus spp., including MRSA and vancomycin resistance Enterococcus spp. isolates.
Databáze: MEDLINE