Anti-aging Effects of Mangosteen Peel Extract and Its Phytochemical Compounds: Antioxidant Activity, Enzyme Inhibition and Molecular Docking Simulation.

Autor: Widowati W; Faculty of Medicine, Maranatha Christian University, Jl. Prof. drg. Surya Sumantri, No. 65, Bandung, West Java 40164, Indonesia., Ginting CN; University of Prima Indonesia, Jl. Sekip Jl. Sikambing No. Simpang, Sei Putih Tim. I, Kec. Medan Petisah, Kota Medan, Sumatera Utara 20111, Indonesia., Lister INE; University of Prima Indonesia, Jl. Sekip Jl. Sikambing No. Simpang, Sei Putih Tim. I, Kec. Medan Petisah, Kota Medan, Sumatera Utara 20111, Indonesia., Girsang E; University of Prima Indonesia, Jl. Sekip Jl. Sikambing No. Simpang, Sei Putih Tim. I, Kec. Medan Petisah, Kota Medan, Sumatera Utara 20111, Indonesia., Amalia A; Biomolecular and Biomedical Research Centre, Aretha Medika Utama, Jl. Babakan Jeruk II No. 9, Sukagalih, Kec. Sukajadi, Kota Bandung, Jawa Barat 40163, Indonesia., Wibowo SHB; Biomolecular and Biomedical Research Centre, Aretha Medika Utama, Jl. Babakan Jeruk II No. 9, Sukagalih, Kec. Sukajadi, Kota Bandung, Jawa Barat 40163, Indonesia., Kusuma HSW; Biomolecular and Biomedical Research Centre, Aretha Medika Utama, Jl. Babakan Jeruk II No. 9, Sukagalih, Kec. Sukajadi, Kota Bandung, Jawa Barat 40163, Indonesia., Rizal; Biomolecular and Biomedical Research Centre, Aretha Medika Utama, Jl. Babakan Jeruk II No. 9, Sukagalih, Kec. Sukajadi, Kota Bandung, Jawa Barat 40163, Indonesia.
Jazyk: angličtina
Zdroj: Tropical life sciences research [Trop Life Sci Res] 2020 Oct; Vol. 31 (3), pp. 127-144. Date of Electronic Publication: 2020 Oct 15.
DOI: 10.21315/tlsr2020.31.3.9
Abstrakt: Skin aging is a complex natural process characterised by gradual diminishment of structural integrity and physiological imbalance of the skin tissue. Since the oxidative stress is tightly corelated to the skin aging process, the usage of antioxidant may serve as favourable strategies for slowing down the skin aging process. Mangosteen is an important fruit commodity and its extract had been extensively studied and revealing various biological activities. Present study aimed to assess the antioxidant and antiaging activity of mangosteen peel extract (MPE) and its phytochemical compounds. MPE and its compounds were subjected to ferric reducing antioxidant power (FRAP), hydroperoxide (H 2 O 2 ) scavenging, anti-collagenase, anti-elastase, anti-hyaluronidase and anti-tyrosinase assay. MPE has the highest FRAP 116.31 ± 0.60 μM Fe(II) μg -1 extract, IC 50 of MPE on H 2 O 2 scavenging activity was 54.61 μg mL -1 . MPE also has the highest anti elastase activity at IC 50 7.40 μg mL -1 . Alpha-mangostin showed potent anti-collagenase activity (IC 50 9.75 μg mL -1 ). While gamma-mangostin showed potent anti-hyaluronidase (IC 50 23.85 μg mL -1 ) and anti-tyrosinase (IC 50 50.35 μg mL -1 ). MPE and its compounds were evaluated in vitro for antioxidant and antiaging activities. Current findings may provide scientific evidence for possible usage of mangosteen extract and its compounds as antioxidant and antiaging agent.
(© Penerbit Universiti Sains Malaysia, 2020.)
Databáze: MEDLINE
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