Whole-body vibration promotes lipid mobilization in hypothalamic obesity rat.

Autor: de Andrade BZ; Bioscience and Health Graduate Program, State University of Western Paraná, Cascavel, PR, 85819-110, Brazil., Zazula MF; Department of Cell Biology, Federal University of Paraná, Curitiba, PR, 81530-000, Brazil., Bittencourt Guimarães AT; Bioscience and Health Graduate Program, State University of Western Paraná, Cascavel, PR, 85819-110, Brazil., Sagae Schneider SC; Bioscience and Health Graduate Program, State University of Western Paraná, Cascavel, PR, 85819-110, Brazil., Boaretto ML; Bioscience and Health Graduate Program, State University of Western Paraná, Cascavel, PR, 85819-110, Brazil., Felicio Poncio AC; Bioscience and Health Graduate Program, State University of Western Paraná, Cascavel, PR, 85819-110, Brazil., Hoff Nunes Maciel JI; Bioscience and Health Graduate Program, State University of Western Paraná, Cascavel, PR, 85819-110, Brazil., de Oliveira CMT; Bioscience and Health Graduate Program, State University of Western Paraná, Cascavel, PR, 85819-110, Brazil., Costa RM; Bioscience and Health Graduate Program, State University of Western Paraná, Cascavel, PR, 85819-110, Brazil., Flor Bertolini GR; Bioscience and Health Graduate Program, State University of Western Paraná, Cascavel, PR, 85819-110, Brazil. Electronic address: gladsonricardo@gmail.com., Chasko Ribeiro LF; Bioscience and Health Graduate Program, State University of Western Paraná, Cascavel, PR, 85819-110, Brazil.
Jazyk: angličtina
Zdroj: Tissue & cell [Tissue Cell] 2021 Feb; Vol. 68, pp. 101456. Date of Electronic Publication: 2020 Oct 30.
DOI: 10.1016/j.tice.2020.101456
Abstrakt: Objectives: This study aimed to analyze the effect of whole-body vibration (WBV) on metabolic parameters using the monosodium l-glutamate (MSG) model of obesity.
Method: MSG-obese rats that were exposed to WBV on a vibrating platform with 60 Hz frequency, 2 mm amplitude, three times/week, 10 min/day, during eight weeks (from postnatal day (PN) 80 to PN136). Blood glucose, creatine kinases (CK and CK-MB) and lipid profile through plasma and liver levels of lipids and lipoproteins were evaluated. Morphology and oxidative stress of adipose and hepatic tissues were further evaluated.
Results: When performing a WBV exercise, animals showed contrasting metabolic responses. Vibration Control group (CTL-WBV) presented a reduction in CK and liver triacylglycerol, an increase in glucose, lactate, total cholesterol, liver cholesterol, and LDL while MSG Vibration group (MSG-WBV) showed an increase in total triacylglycerol, VLDL, lactate, CK, liver cholesterol, additional liver lipid peroxidation and LDL, total cholesterol and CKMB reduction.
Conclusion: Even although the MSG is a model of impacting injury, the metabolic demand of WBV exercise was able to induce mobilization of substrates, highlighting the lipid mobilization in obese animals, it should be used as a metabolic rehabilitation tool in patients with metabolic diseases, such as obesity and diabetes.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: