Kratom induced severe cholestatic liver injury histologically mimicking primary biliary cholangitis: A case report.
| Autor: | Gandhi D; Department of Radiology, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States. darshangandhi7@gmail.com., Ahuja K; Department of Internal Medicine, Maulana Azad Medical College, New Delhi 110002, Delhi, India., Quade A; Internal Medicine-Pediatrics, University of California-San Diego and Rady Children's Hospital San Diego, San Diego, CA 92103, United States., Batts KP; Department of Pathology, Abbott Northwestern Hospital, Allina Health, Minneapolis, MN 55407, United States., Patel L; Division of Hospital Medicine, Abbott Northwestern Hospital, Allina Health, Minneapolis, MN 55407, United States. |
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| Jazyk: | angličtina |
| Zdroj: | World journal of hepatology [World J Hepatol] 2020 Oct 27; Vol. 12 (10), pp. 863-869. |
| DOI: | 10.4254/wjh.v12.i10.863 |
| Abstrakt: | Background: Kratom is a psychoactive substance that is isolated from the plant Mitragyna speciosa . The leaves can be chewed fresh or dried, smoked, or infused similar to herbal teas. The plant leaves have been used by natives of Southeast Asia for centuries. The substance has been used for its stimulant activity at low doses, and as an opium substitute at higher doses due to a morphine like effect. Case Summary: A 37-year-old female with a history of depression and obesity (body mass index: 32) presented to emergency room with a week-long history of nausea, decreased appetite, fatigue, and two days of jaundice. On admission bilirubin was markedly elevated. Her condition was thought to be due to consumption of Kratom 2 wk before onset of symptoms. Liver biopsy showed changes mimicking primary biliary cholangitis. Patient's symptoms and jaundice improved quickly. Conclusion: The use of Kratom has been on the rise in recent years across the United States and Europe. Several case reports have associated adverse health impact of Kratom-containing products including death due to its ability to alter levels of consciousness. Only a few case reports have highlighted the hepatotoxic effects of Kratom. Even fewer reports exist describing the detailed histopathological changes. (©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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