Application of a flexible polymer microECoG array to map functional coherence in schizophrenia model.

Autor:	Fedor FZ; Doctoral School of Chemical Engineering and Material Sciences, Pannon University, Veszprém, Hungary.; ELTE NAP Neuroimmunology Research Group, Department of Biochemistry, Institute of Biology, Eötvös Loránd University, Budapest, Hungary.; Research Group for Implantable Microsystems, Faculty of Information Technology & Bionics, Pázmány Péter Catholic University, Budapest, Hungary., Zátonyi A; ELTE NAP Neuroimmunology Research Group, Department of Biochemistry, Institute of Biology, Eötvös Loránd University, Budapest, Hungary.; Centre for Energy Research, Hungarian Academy of Sciences, Budapest, Hungary.; Research Group for Implantable Microsystems, Faculty of Information Technology & Bionics, Pázmány Péter Catholic University, Budapest, Hungary., Cserpán D; Theoretical Neuroscience and Complex Systems Research Group, Department of Computational Sciences, Wigner Research Centre for Physics, Budapest, Hungary., Somogyvári Z; Theoretical Neuroscience and Complex Systems Research Group, Department of Computational Sciences, Wigner Research Centre for Physics, Budapest, Hungary., Borhegyi Z; Department of Biochemistry, Eötvös Loránd University, Budapest, Hungary., Juhász G; Department of Biochemistry, Eötvös Loránd University, Budapest, Hungary., Fekete Z; Centre for Energy Research, Hungarian Academy of Sciences, Budapest, Hungary.; Research Group for Implantable Microsystems, Faculty of Information Technology & Bionics, Pázmány Péter Catholic University, Budapest, Hungary.
Jazyk:	angličtina
Zdroj:	MethodsX [MethodsX] 2020 Oct 22; Vol. 7, pp. 101117. Date of Electronic Publication: 2020 Oct 22 (Print Publication: 2020).
DOI:	10.1016/j.mex.2020.101117
Abstrakt:	Anatomically, connections form the fundamental brain network, functionally the different types of oscillatory electric activities are creating a temporarily connected fraction of the anatomical connectome generating an output to the motor system. Schizophrenia can be considered as a connectome disease, in which the sensory input generates a schizophrenia specific temporary connectome and the signal processing becomes diseased showing hallucinations and adverse behavioral reactions. In this work, flexible, 32-channel polymer microelectrode arrays fabricated by the authors are used to map the functional coherence on large cortical areas during physiological activities in a schizophrenia model in rats.-Fabrication of a flexible microECoG array is shown.-Protocol to use a flexible microECoG is demonstrated to characterize connectome diseases in rats.-Customized method to analyze the functional coherence between different cortical areas during visually evoked potential is detailed.-R-based implementation of the analysis method is presented. (© 2020 The Author(s). Published by Elsevier B.V.)
Databáze:	MEDLINE
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