Impact of local treatment on survival from hematological malignancies causing spinal cord compression.

Autor:	Ghedira H; Department of Hematology Bab Saadoun, Tunis, Tunisia., Radhouane K; Department of Neurosurgery, Military Hospital of Tunis, Bab Saadoun, Tunis, Tunisia., Mezni E; Department of Hematology Bab Saadoun, Tunis, Tunisia., Yahiaoui S; Department of Radiotherapy, Salah Azaiez Institue, Bab Saadoun, Tunis, Tunisia., Stambouli H; Department of Hematology Bab Saadoun, Tunis, Tunisia., Yedeas MD; Department of Neurosurgery, Military Hospital of Tunis, Bab Saadoun, Tunis, Tunisia., Belaid A; Department of Radiotherapy, Salah Azaiez Institue, Bab Saadoun, Tunis, Tunisia., Ammar C; Department of Radiotherapy, Salah Azaiez Institue, Bab Saadoun, Tunis, Tunisia., Kacem K; Department of Hematology, Aziza Othmana University Hospital, Faculty of Medecine of Tunis, University Tunis El Manar, Bab Saadoun, Tunis, Tunisia., Zriba S; Department of Hematology Bab Saadoun, Tunis, Tunisia., Msadek F; Department of Hematology Bab Saadoun, Tunis, Tunisia., Yedeas M; Department of Neurosurgery, Military Hospital of Tunis, Bab Saadoun, Tunis, Tunisia., Harbaoui A; Department of Neurosurgery, Military Hospital of Tunis, Bab Saadoun, Tunis, Tunisia., Chkili R; Department of Neurosurgery, Military Hospital of Tunis, Bab Saadoun, Tunis, Tunisia.
Jazyk:	angličtina
Zdroj:	Surgical neurology international [Surg Neurol Int] 2020 Oct 21; Vol. 11, pp. 352. Date of Electronic Publication: 2020 Oct 21 (Print Publication: 2020).
DOI:	10.25259/SNI_592_2020
Abstrakt:	Background: Various hematological malignancies, including multiple myeloma, plasmacytoma, aggressive lymphoma, and indolent lymphoma, rarely result in spinal cord compression. Methods: Here, we retrospectively analyzed 32 patients with multiple myeloma (50%), plasmacytoma (13%), aggressive lymphoma (28%), and indolent lymphoma (9%), resulting in spinal cord compression (2004 and 2016). Patients averaged 57 years of age and presented with the indolent onset of spinal cord compression (91% of cases) resulting mostly in motor deficits (69%). Results: Local treatment modalities included radiotherapy (RT) (28%) alone, decompressive surgery (28%) alone, or decompressive surgery with consolidation RT (40%). The 1-year overall survival was 70%, and the progression-free survival frequency was 62%. Conclusion: This study highlighted the importance of standardizing the indications for RT alone versus RT with surgery depending on the patient's underlying pathological diagnosis, neurological deficits, and radiological findings. Competing Interests: There are no conflicts of interest. (Copyright: © 2020 Surgical Neurology International.)
Databáze:	MEDLINE
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