A comparison of digital chest radiography and Xpert ® MTB/RIF in active case finding for tuberculosis.

Autor:	Nguyen TBP; Woolcock Institute of Medical Research, Hanoi, Viet Nam., Nguyen TA; Woolcock Institute of Medical Research, Hanoi, Viet Nam, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., Luu BK; Woolcock Institute of Medical Research, Hanoi, Viet Nam., Le TTO; Woolcock Institute of Medical Research, Hanoi, Viet Nam., Nguyen VS; National TB Control Programme, Hanoi, Centre for Social Disease Control, Ca Mau., Nguyen KC; National Lung Hospital, Hanoi, Hanoi Medical University, Hanoi., Duong KD; University of Medicine and Pharmacy, Ho Chi Minh city, Viet Nam., Nguyen HB; National TB Control Programme, Hanoi, National Lung Hospital, Hanoi, Centre for Operational Research, International Union Against Tuberculosis and Lung Disease, Paris, France., Nguyen NL; Global Tuberculosis Program, World Health Organization, Geneva, Switzerland., Fox GJ; Woolcock Institute of Medical Research, Hanoi, Viet Nam, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., Nguyen NV; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia, National TB Control Programme, Hanoi, National Lung Hospital, Hanoi, Hanoi Medical University, Hanoi., Marks GB; Woolcock Institute of Medical Research, Hanoi, Viet Nam, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia, South Western Sydney Clinical School, University of NSW, Sydney, NSW, Australia.
Jazyk:	angličtina
Zdroj:	The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2020 Sep 01; Vol. 24 (9), pp. 934-940.
DOI:	10.5588/ijtld.19.0764
Abstrakt:	OBJECTIVE: To compare two community screening tests for TB: sputum examination using Xpert ® MTB/RIF and chest radiography (CXR). METHOD: Men aged ≥15 years and women aged >45 years living in 96 sub-communes in Ca Mau, Viet Nam, were invited to provide a single sputum specimen that was tested using Xpert. Participants were also invited to attend a nearby location for digital radiography. Participants whose sputum was Xpert MTB-positive or whose CXR was reported as 'consistent with TB´ were requested to provide two further sputum specimens for culture. The sensitivities of the two tests for detecting TB (defined as sputum culture-positive for Mycobacterium tuberculosis ) were compared. RESULTS: There were 72 985 eligible participants, of whom 57 597 (78.9%) participated in Xpert screening, 12 752 (17.5%) had CXR and 11 235 (15.4%) had both tests. We estimated that there were 59 cases of TB, of whom 20 were Xpert MTB-positive (programmatic sensitivity 34.0%) and 47 had CXR reported as 'consistent with TB´ (sensitivity 80.0%, P < 0.0001). CONCLUSION: In community-wide screening for TB, CXR is more sensitive than a single spontaneously expectorated sputum sample tested using Xpert, but it has a substantially lower participation rate.
Databáze:	MEDLINE
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