CXCL10 immunomodulatory effect against infection caused by an antimony refractory isolate of Leishmania braziliensis in mice.

Autor: Dutra BM; Department of Pathology and Legal Medicine, Federal University of Ceará, Fortaleza, Brazil., Rodrigues NLC; Department of Pathology and Legal Medicine, Federal University of Ceará, Fortaleza, Brazil., Fonseca FRM; Department of Pathology and Legal Medicine, Federal University of Ceará, Fortaleza, Brazil., de Moura TR; Department of Internal Medicine and Pathology, Federal University of Sergipe, Aracajú, Brazil., Pacheco de Almeida R; Department of Internal Medicine and Pathology, Federal University of Sergipe, Aracajú, Brazil., de Jesus AR; Department of Internal Medicine and Pathology, Federal University of Sergipe, Aracajú, Brazil., Abreu TM; Department of Pathology and Legal Medicine, Federal University of Ceará, Fortaleza, Brazil., Pompeu MML; Department of Pathology and Legal Medicine, Federal University of Ceará, Fortaleza, Brazil., Teixeira CR; Fiocruz Ceará, Oswaldo Cruz Foundation, Eusébio, Brazil., Teixeira MJ; Department of Pathology and Legal Medicine, Federal University of Ceará, Fortaleza, Brazil.
Jazyk: angličtina
Zdroj: Parasite immunology [Parasite Immunol] 2021 Mar; Vol. 43 (3), pp. e12805. Date of Electronic Publication: 2020 Nov 19.
DOI: 10.1111/pim.12805
Abstrakt: Leishmania braziliensis is the main causative agent of American tegumentary leishmaniasis in Brazil. Current treatment includes different drugs that have important side effects and identification of cases of parasite resistance to treatment support the search for new therapeutic strategies. Recent findings have indicated that CXCL10, a chemokine that recruits and activates Th1 cells, NK cells, macrophages, dendritic cells and B lymphocytes, is a potential alternative to treat Leishmania infection. Here, we tested CXCL10 immunotherapy against experimental infection caused by an antimony-resistant isolate of Leishmania braziliensis. Following infection, mice were treated with CXCL10 for 7 days after onset of lesions. We demonstrate that mice treated with CXCL10 controlled lesion progression and parasite burden more efficiently comparing to controls. An increased IFN-γ, IL-10, TGF-β and low IL-4 production combined with a distinct inflammatory infiltrate composed by activated macrophages, lymphocytes and granulomas was observed in the CXCL10-treated group comparing to controls. However, CXCL10 and Glucantime combined therapy did not improve CXCL10-induced protective effect. Our findings reinforce the potential of CXCL10 immunotherapy as an alternative treatment against infection caused by L. braziliensis resistant to conventional chemotherapy.
(© 2020 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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