Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2.

Autor: Kandeil A; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Gomaa MR; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., El Taweel A; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Mostafa A; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Shehata M; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Kayed AE; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Kutkat O; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Moatasim Y; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Mahmoud SH; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Kamel MN; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Shama NMA; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., El Sayes M; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., El-Shesheny R; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt., Yassien MA; Biological Sector, Egyptian Drug Authority, Cairo, Egypt., Webby RJ; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America., Kayali G; Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas, Houston, Texas, United States of America.; Human Link, Hazmieh, Baabda, Lebanon., Ali MA; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2020 Oct 28; Vol. 15 (10), pp. e0241471. Date of Electronic Publication: 2020 Oct 28 (Print Publication: 2020).
DOI: 10.1371/journal.pone.0241471
Abstrakt: Anecdotal evidence showed a negative correlation between Bacille Calmette-Guérin (BCG) vaccination and incidence of COVID-19. Incidence of the disease in children is much lower than in adults. It is hypothesized that BCG and other childhood vaccinations may provide some protection against SARS-CoV-2 infection through trained or adaptive immune responses. Here, we tested whether BCG, Pneumococcal, Rotavirus, Diphtheria, Tetanus, Pertussis, Hepatitis B, Haemophilus influenzae, Hepatitis B, Meningococcal, Measles, Mumps, and Rubella vaccines provide cross-reactive neutralizing antibodies against SARS-CoV-2 in BALB/c mice. Results indicated that none of these vaccines provided antibodies capable of neutralizing SARS-CoV-2 up to seven weeks post vaccination. We conclude that if such vaccines have any role in COVID-19 immunity, this role is not antibody-mediated.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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