Development of a multiomics database for personalized prognostic forecasting in head and neck cancer: The Big Data to Decide EU Project.

Autor: Cavalieri S; Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., De Cecco L; Integrated Biology Platform, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Brakenhoff RH; Vrije Universiteit Amsterdam, Otolaryngology/Head and Neck Surgery, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, The Netherlands., Serafini MS; Integrated Biology Platform, Department of Applied Research and Technology Development, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Canevari S; Fondazione IRCCS Istituto Nazionale dei Tumori di Milano. Milan, Italy., Rossi S; Unit of Maxillofacial Surgery, Department of Medicine and Surgery, University of Parma - University Hospital of Parma, Parma, Italy., Lanfranco D; Unit of Maxillofacial Surgery, Department of Medicine and Surgery, University of Parma - University Hospital of Parma, Parma, Italy., Hoebers FJP; Department of Radiation Oncology (MAASTRO), Research Institute GROW, Maastricht University, Maastricht, The Netherlands., Wesseling FWR; Department of Radiation Oncology (MAASTRO), Research Institute GROW, Maastricht University, Maastricht, The Netherlands., Keek S; The D-Lab, Department of Precision Medicine, GROW- School for Oncology, Maastricht University Medical Center, Maastricht, The Netherlands., Scheckenbach K; Department of Otolaryngology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Mattavelli D; Department of Otorhinolaryngology Head and Neck Surgery, Spedali Civili di Brescia and University of Brescia, Brescia, Italy., Hoffmann T; Department of Otorhinolaryngology Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany., López Pérez L; Life Supporting Technologies, Photonics Technology and Bioengineering Department, School of Telecommunication Engineering, Universidad Politécnica de Madrid, Madrid, Spain., Fico G; Life Supporting Technologies, Photonics Technology and Bioengineering Department, School of Telecommunication Engineering, Universidad Politécnica de Madrid, Madrid, Spain., Bologna M; Department of Electronics, Information and Bioengineering (DEIB) Politecnico di Milano, Politecnico di Milano, Milan, Italy., Nauta I; Vrije Universiteit Amsterdam, Otolaryngology/Head and Neck Surgery, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, The Netherlands., Leemans CR; Vrije Universiteit Amsterdam, Otolaryngology/Head and Neck Surgery, Amsterdam UMC, Cancer Center Amsterdam, Amsterdam, The Netherlands., Trama A; Department of Preventive and Predictive Medicine, Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Klausch T; Department of Epidemiology and Data Science, Public Health Research Institute Amsterdam - Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Berkhof JH; Department of Epidemiology and Data Science, Public Health Research Institute Amsterdam - Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Tountopoulos V; Technical Implementation, Innovation Lab, Athens Technology Center, Athens, Greece., Shefi R; All-In-Image Ltd, Israel., Mainardi L; Department of Electronics, Information and Bioengineering (DEIB) Politecnico di Milano, Politecnico di Milano, Milan, Italy., Mercalli F; MultiMed Engineers srl, Parma, Italy., Poli T; Unit of Maxillofacial Surgery, Department of Medicine and Surgery, University of Parma - University Hospital of Parma, Parma, Italy., Licitra L; Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2021 Feb; Vol. 43 (2), pp. 601-612. Date of Electronic Publication: 2020 Oct 27.
DOI: 10.1002/hed.26515
Abstrakt: Background: Despite advances in treatments, 30% to 50% of stage III-IV head and neck squamous cell carcinoma (HNSCC) patients relapse within 2 years after treatment. The Big Data to Decide (BD2Decide) project aimed to build a database for prognostic prediction modeling.
Methods: Stage III-IV HNSCC patients with locoregionally advanced HNSCC treated with curative intent (1537) were included. Whole transcriptomics and radiomics analyses were performed using pretreatment tumor samples and computed tomography/magnetic resonance imaging scans, respectively.
Results: The entire cohort was composed of 71% male (1097)and 29% female (440): oral cavity (429, 28%), oropharynx (624, 41%), larynx (314, 20%), and hypopharynx (170, 11%); median follow-up 50.5 months. Transcriptomics and imaging data were available for 1284 (83%) and 1239 (80%) cases, respectively; 1047 (68%) patients shared both.
Conclusions: This annotated database represents the HNSCC largest available repository and will enable to develop/validate a decision support system integrating multiscale data to explore through classical and machine learning models their prognostic role.
(© 2020 The Authors. Head & Neck published by Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: