| Autor: |
Cavalcanti BC; Drug Research and Development Center, Federal University of Ceará , Fortaleza, Brazil.; Department of Physiology and Pharmacology, Federal University of Ceará , Fortaleza, CE, Brazil., Neto JBA; Drug Research and Development Center, Federal University of Ceará , Fortaleza, Brazil.; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules, Federal University of Ceará , Fortaleza, Brazil.; Christus University Center (UNICHRISTUS) , Fortaleza, Brazil., Silva AAS; Drug Research and Development Center, Federal University of Ceará , Fortaleza, Brazil., Barreto FS; Drug Research and Development Center, Federal University of Ceará , Fortaleza, Brazil., Ferreira JRO; School of Medical Sciences, State University of Health Sciences of Alagoas , Maceió, Brazil., Magalhães HIF; Department of Pharmaceutical Sciences, Federal University of Paraiba , João Pessoa, Brazil., Silva CRD; Drug Research and Development Center, Federal University of Ceará , Fortaleza, Brazil.; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules, Federal University of Ceará , Fortaleza, Brazil., Vieira ÍGP; Department of Organic and Inorganic Chemistry, Federal University of Ceará , Fortaleza, Brazil., Ricardo NMPS; Department of Organic and Inorganic Chemistry, Federal University of Ceará , Fortaleza, Brazil., Nobre Júnior HV; Drug Research and Development Center, Federal University of Ceará , Fortaleza, Brazil.; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules, Federal University of Ceará , Fortaleza, Brazil., Moraes MO; Drug Research and Development Center, Federal University of Ceará , Fortaleza, Brazil.; Department of Physiology and Pharmacology, Federal University of Ceará , Fortaleza, CE, Brazil. |
| Abstrakt: |
Troxerutin is a natural flavonoid present abundantly in tea, coffee, olives, wheat, and a variety of fruits and vegetables. Due to its diverse pharmacological properties, this flavonoid has aroused interest for treatment of various diseases, and consequently prompted investigation into its toxicological characteristics. The aim of this study was to evaluate the genotoxic and mutagenic effects and chemoprotective activity attributed to troxerutin using human peripheral blood leukocytes (PBLs) through several well-established experimental protocols based upon different parameters. Data demonstrated that troxerutin (100 to 1000 µM) induced no marked cytotoxic effect on PBLs after 24 hr, and did not produce strand breaks and mutagenicity. Regarding chemoprevention, this flavonoid attenuated cytotoxicity, genotoxicity, and mutagenicity initiated by hydrogen peroxide (H 2 O 2 ) in human PBLs. Further, troxerutin demonstrated no marked cytotoxic effect on PBLs and exerted a protective effect against oxidative stress induced by H 2 O 2 through modulation of GSH-dependent enzymes. |
