Prenatal air pollution exposure and neurodevelopment: A review and blueprint for a harmonized approach within ECHO.

Autor: Volk HE; Department of Mental Health and Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. Electronic address: hvolk1@jhu.edu., Perera F; Columbia Center for Children's Environmental Health, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA., Braun JM; Department of Epidemiology, Brown University, Providence, RI, USA., Kingsley SL; Department of Epidemiology, Brown University, Providence, RI, USA., Gray K; National Institute of Environmental Health Sciences, Durham, NC, USA., Buckley J; Department of Environmental Health and Engineering and Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA., Clougherty JE; Department of Environmental and Occupational Health, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA., Croen LA; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Eskenazi B; Center for Environmental Research and Children's Health, School of Public Health, University of California Berkeley, Berkeley, CA, USA., Herting M; Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Just AC; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kloog I; Department of Geography and Environmental Development, Faculty of Humanities and Social Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel., Margolis A; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA., McClure LA; Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA., Miller R; Department of Medicine, Department of Pediatrics, The College of Physicians and Surgeons, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA., Levine S; Columbia Center for Children's Environmental Health, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA., Wright R; Department of Environmental Medicine and Public Health, And Pediatrics, Institute for Exposomics Research, Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2021 May; Vol. 196, pp. 110320. Date of Electronic Publication: 2020 Oct 22.
DOI: 10.1016/j.envres.2020.110320
Abstrakt: Background: Air pollution exposure is ubiquitous with demonstrated effects on morbidity and mortality. A growing literature suggests that prenatal air pollution exposure impacts neurodevelopment. We posit that the Environmental influences on Child Health Outcomes (ECHO) program will provide unique opportunities to fill critical knowledge gaps given the wide spatial and temporal variability of ECHO participants.
Objectives: We briefly describe current methods for air pollution exposure assessment, summarize existing studies of air pollution and neurodevelopment, and synthesize this information as a basis for recommendations, or a blueprint, for evaluating air pollution effects on neurodevelopmental outcomes in ECHO.
Methods: We review peer-reviewed literature on prenatal air pollution exposure and neurodevelopmental outcomes, including autism spectrum disorder, attention deficit hyperactivity disorder, intelligence, general cognition, mood, and imaging measures. ECHO meta-data were compiled and evaluated to assess frequency of neurodevelopmental assessments and prenatal and infancy residential address locations. Cohort recruitment locations and enrollment years were summarized to examine potential spatial and temporal variation present in ECHO.
Discussion: While the literature provides compelling evidence that prenatal air pollution affects neurodevelopment, limitations in spatial and temporal exposure variation exist for current published studies. As >90% of the ECHO cohorts have collected a prenatal or infancy address, application of advanced geographic information systems-based models for common air pollutant exposures may be ideal to address limitations of published research.
Conclusions: In ECHO we have the opportunity to pioneer unifying exposure assessment and evaluate effects across multiple periods of development and neurodevelopmental outcomes, setting the standard for evaluation of prenatal air pollution exposures with the goal of improving children's health.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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